Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Muscogiuri, G; Altieri, B; Annweiler, C; Balercia, G; Pal, HB; Boucher, BJ; Cannell, JJ; Foresta, C; Grübler, MR; Kotsa, K; Mascitelli, L; März, W; Orio, F; Pilz, S; Tirabassi, G; Colao, A.
Vitamin D and chronic diseases: the current state of the art.
Arch Toxicol. 2017; 91(1):97-107
Doi: 10.1007/s00204-016-1804-x
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Grübler Martin
- März Winfried
- Pilz Stefan
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- Abstract:
- The objective was to provide the current state of the art regarding the role of vitamin D in chronic diseases (osteoporosis, cancer, cardiovascular diseases, dementia, autism, type 1 and type 2 diabetes mellitus, male and female fertility). The document was drawn up by panelists that provided their contribution according to their own scientific expertise. Each scientific expert supplied a first draft manuscript on a specific aspect of the document's topic that was subjected to voting by all experts as "yes" (agreement with the content and/or wording) or "no" (disagreement). The adopted rule was that statements supported by ≥75 % of votes would be immediately accepted, while those with <25 % would be rejected outright. Others would be subjected to further discussion and subsequent voting, where ≥67 % support or, in an eventual third round, a majority of ≥50 % would be needed. This document finds that the current evidence support a role for vitamin D in bone health but not in other health conditions. However, subjects with vitamin D deficiency have been found to be at high risk of developing chronic diseases. Therefore, although at the present time there is not sufficient evidence to recommend vitamin D supplementation as treatment of chronic diseases, the treatment of vitamin D deficiency should be desiderable in order to reduce the risk of developing chronic diseases.
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