Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reichmann, F; Wegerer, V; Jain, P; Mayerhofer, R; Hassan, AM; Fröhlich, EE; Bock, E; Pritz, E; Herzog, H; Holzer, P; Leitinger, G.
Environmental enrichment induces behavioural disturbances in neuropeptide Y knockout mice.
Sci Rep. 2016; 6(2):28182-28182
Doi: 10.1038/srep28182
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- Führende Autor*innen der Med Uni Graz
- Leitinger Gerd
- Reichmann Florian
- Co-Autor*innen der Med Uni Graz
- Bock Elisabeth
- Fröhlich Esther Eleonore
- Hassan Ahmed
- Holzer Peter
- JAIN Piyush
- Mayerhofer Raphaela
- Pritz Elisabeth
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- Abstract:
- Environmental enrichment (EE) refers to the provision of a complex and stimulating housing condition which improves well-being, behaviour and brain function of laboratory animals. The mechanisms behind these beneficial effects of EE are only partially understood. In the current report, we describe a link between EE and neuropeptide Y (NPY), based on findings from NPY knockout (KO) mice exposed to EE. Relative to EE-housed wildtype (WT) animals, NPY KO mice displayed altered behaviour as well as molecular and morphological changes in amygdala and hippocampus. Exposure of WT mice to EE reduced anxiety and decreased central glucocorticoid receptor expression, effects which were absent in NPY KO mice. In addition, NPY deletion altered the preference of EE items, and EE-housed NPY KO mice responded to stress with exaggerated hyperthermia, displayed impaired spatial memory, had higher hippocampal brain-derived neurotrophic factor mRNA levels and altered hippocampal synaptic plasticity, effects which were not seen in WT mice. Accordingly, these findings suggest that NPY contributes to the anxiolytic effect of EE and that NPY deletion reverses the beneficial effects of EE into a negative experience. The NPY system could thus be a target for "enviromimetics", therapeutics which reproduce the beneficial effects of enhanced environmental stimulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anxiety - genetics
- Behavior, Animal - physiology
- Brain-Derived Neurotrophic Factor - genetics
- Fever - genetics
- Fever - pathology
- Housing, Animal -
- Male -
- Maze Learning -
- Mice -
- Mice, Inbred C57BL -
- Mice, Knockout -
- Neuronal Plasticity - genetics
- Neuropeptide Y - genetics
- Neuropeptide Y - metabolism
- RNA, Messenger - biosynthesis
- Receptors, Glucocorticoid - metabolism
- Spatial Memory - physiology