Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wolf, P; Weger, W; Patra, V; Gruber-Wackernagel, A; Byrne, SN.
Desired response to phototherapy vs photoaggravation in psoriasis: what makes the difference?
Exp Dermatol. 2016; 25(12):937-944
Doi: 10.1111/exd.13137
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- Leading authors Med Uni Graz
- Wolf Peter
- Co-authors Med Uni Graz
- Gruber-Wackernagel Alexandra
- Patra Vijaykumar
- Weger Wolfgang
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- Abstract:
- Psoriasis commonly responds beneficially to UV radiation from natural sunlight or artificial sources. Therapeutic mechanisms include the proapoptotic and immunomodulating effects of UV, affecting many cells and involving a variety of pro- and anti-inflammatory cytokines, downregulating the Th17/IL-23 response with simultaneous induction of regulatory immune cells. However, exposure to UV radiation in a subset of psoriasis patients leads to exacerbation of the disease. We herein shed light on the predisposing factors of photosensitive psoriasis, including genetics (such as HLA-Cw*0602 or CARD14), gender and coexisting photodermatoses such as polymorphic light eruption (PLE) in the context of potential molecular mechanisms behind therapeutic photoresponsiveness or photoaggravation. UV-induced damage/pathogen-associated molecular patterns, damage to self-coding RNA (signalling through Toll-like receptors), certain antimicrobial peptides and/or inflammasome activation may induce innate immunity, leading to psoriasis at the site of UV exposure when there is concomitant, predisposing resistance against UV-induced suppression of the adaptive immune response (like in PLE) that otherwise would act to reduce psoriasis. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- CARD Signaling Adaptor Proteins - genetics
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- Membrane Proteins - genetics
- Photosensitivity Disorders - genetics
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- Psoriasis - genetics
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- Find related publications in this database (Keywords)
- Koebner phenomenon
- photoaggravation
- photosensitivity
- phototherapy
- polymorphic light eruption
- psoriasis