Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Wagner, H; Kriegshäuser, G; Kimbacher, C; Stolba, R; Worf, E; Halwachs-Baumann, G.
Hepcidin-25 vs. conventional clinical biomarkers in the diagnosis of functional iron deficiency.
Eur J Haematol. 2015; 95(6):507-513
Doi: 10.1111/ejh.12523
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Kriegshäuser Gernot
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- Abstract:
- As hepcidin-25 is considered as a key regulator of human iron homoeostasis, this study aimed to compare this parameter with conventional biomarkers and diagnostic tools of iron deficiency (ID). In total, 233 hospitalised adult patients, who underwent routine blood testing for ID, were included. All subjects were investigated for hepcidin-25, reticulocyte haemoglobin content (CHr), soluble transferrin receptor (sTfR)/log ferritin ratio (i.e. Thomas plot), sTfR, ferritin, transferrin saturation (TSAT), C-reactive protein (CRP) and for complete blood cell count. Functional ID was defined as a CHr < 28 pg. Separate logistic regression models were calculated with all potential biomarkers to evaluate and compare the predictive performance with respect to functional ID in patients without (CRP ≤ 0.5 mg/dL) and with (CRP > 0.5 mg/dL) acute-phase reaction, respectively. One hundred seventeen patients with CRP > 0.5 mg/dL showed a distinctly higher hepcidin-25 median value [35.60 (range: 4.27-80.03) ng/mL] as compared to 116 patients with CRP ≤ 0.5 mg/dL [18.55 (range: 3.77-73.01) ng/mL]. With respect to functional ID, sTfR/log ferritin ratio and sTfR were of better positive predictive value (PPV) (sTfR/log ferritin ratio: 58.33% and 70.83%; sTfR: 60.00% and 60.00%) than when compared to hepcidin-25 (PPV: 37.74% and 42.86%) and ferritin (PPV: 27.54% and 46.15%) in both subgroups. The sTfR/log ferritin ratio, as well as sTfR, were better predictors of functional ID in patients with and without acute-phase reaction as compared to hepcidin-25 and ferritin. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anemia, Iron-Deficiency - blood
- Anemia, Iron-Deficiency - diagnosis
- Anemia, Iron-Deficiency - metabolism
- Biomarkers -
- Erythrocyte Indices -
- Female -
- Hepcidins - blood
- Hospitalization -
- Humans -
- Iron - metabolism
- Male -
- Middle Aged -
- ROC Curve -
- Reticulocyte Count -
- Young Adult -
- Find related publications in this database (Keywords)
- hepcidin-25
- diagnostic implication
- functional iron deficiency