Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ulz, P; Belic, J; Graf, R; Auer, M; Lafer, I; Fischereder, K; Webersinke, G; Pummer, K; Augustin, H; Pichler, M; Hoefler, G; Bauernhofer, T; Geigl, JB; Heitzer, E; Speicher, MR.
Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer.
Nat Commun. 2016; 7(15):12008-12008
Doi: 10.1038/ncomms12008
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Belic Jelena
- Heitzer Ellen
- Ulz Peter
- Co-Autor*innen der Med Uni Graz
- Auer Martina
- Augustin Herbert
- Bauernhofer Thomas
- Fischereder Katja
- Geigl Jochen Bernd
- Graf Ricarda
- Höfler Gerald
- Lafer Ingrid
- Pichler Martin
- Pummer Karl
- Speicher Michael
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome plasma sequencing on 95 plasma samples derived from 43 patients with metastatic prostate cancer. From these samples, we identify established driver aberrations in a cancer-related gene in nearly all cases (97.7%), including driver gene fusions (TMPRSS2:ERG), driver focal deletions (PTEN, RYBP and SHQ1) and driver amplifications (AR and MYC). In serial plasma analyses, we observe changes in focal amplifications in 40% of cases. The mean time interval between new amplifications was 26.4 weeks (range: 5-52 weeks), suggesting that they represent rapid adaptations to selection pressure. An increase in neuron-specific enolase is accompanied by clonal pattern changes in the tumour genome, most consistent with subclonal diversification of the tumour. Our findings suggest a high plasticity of prostate cancer genomes with newly occurring focal amplifications as a driving force in progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Biopsy -
- Cell Differentiation -
- Chromosome Aberrations -
- Cluster Analysis -
- DNA, Neoplasm - genetics
- Disease Progression -
- Gene Deletion -
- Gene Dosage -
- Genome, Human -
- Humans -
- Male -
- Neoplasm Metastasis -
- Prostate-Specific Antigen - blood
- Prostatic Neoplasms - blood
- Prostatic Neoplasms - genetics
- Proto-Oncogene Proteins c-myc - genetics
- Sequence Analysis, DNA -