Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Prattes, J; Duettmann, W; Hoenigl, M.
Posaconazole Plasma Concentrations on Days Three to Five Predict Steady-State Levels.
Antimicrob Agents Chemother. 2016; 60(9):5595-5599
Doi: 10.1128/AAC.00389-16
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Prattes Jürgen
- Co-Autor*innen der Med Uni Graz
- Düttmann Wiebke
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- Abstract:
- Low posaconazole plasma concentrations (PPCs) have been associated with breakthrough invasive fungal infections. We assessed the correlation between pre-steady-state PPCs (obtained between days 3 and 5) and PPCs obtained during steady state in 48 patients with underlying hematological malignancies receiving posaconazole oral-solution prophylaxis. Pre-steady-state PPCs correlated significantly with PPCs obtained at steady state (Spearman r = 0.754; P < 0.001). Receiver operating characteristic (ROC) curve analysis of pre-steady-state PPCs revealed an area under the curve (AUC) of 0.884 (95% confidence interval [CI], 0.790 to 0.977) for predicting satisfactory PPCs at steady state. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Aged -
- Aged, 80 and over -
- Antifungal Agents - blood
- Antifungal Agents - pharmacokinetics
- Antifungal Agents - therapeutic use
- Area Under Curve -
- Drug Monitoring -
- Female -
- Hematologic Neoplasms - blood
- Humans -
- Male -
- Middle Aged -
- Mycoses - blood
- Mycoses - drug therapy
- ROC Curve -
- Triazoles - blood
- Triazoles - pharmacokinetics
- Triazoles - therapeutic use