Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Longhurst, HJ; Aberer, W; Bouillet, L; Caballero, T; Maurer, M; Fabien, V; Zanichelli, A; IOS Study Group.
The Icatibant Outcome Survey: treatment of laryngeal angioedema attacks.
Eur J Emerg Med. 2016; 23(3):224-227
Doi: 10.1097/MEJ.0000000000000292
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- To characterize the management and outcomes of life-threatening laryngeal attacks of hereditary angioedema (HAE) treated with icatibant in the observational Icatibant Outcome Survey (NCT01034969) registry. This retrospective analysis was based on data from patients with HAE type I/II who received healthcare professional-administered or self-administered icatibant to treat laryngeal attacks between September 2008 and May 2013. Twenty centers in seven countries contributed data. Overall, 42 patients with HAE experienced 67 icatibant-treated laryngeal attacks. Icatibant was self-administered for 62.3% of attacks (healthcare professional-administered, 37.7%). One icatibant injection was used for 87.9% of attacks, with rescue or concomitant medication used for 9.0%. The median time to treatment was 2.0 h (n=31 attacks) and the median time to resolution was 6.0 h (n=35 attacks). This analysis describes successful use of icatibant for the treatment of laryngeal HAE attacks in a real-world setting.
- Find related publications in this database (using NLM MeSH Indexing)
- Angioedemas, Hereditary - drug therapy
- Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
- Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
- Bradykinin - administration & dosage
- Bradykinin - analogs & derivatives
- Bradykinin - therapeutic use
- Female -
- Hereditary Angioedema Types I and II - drug therapy
- Humans -
- Injections, Subcutaneous -
- Laryngeal Diseases - drug therapy
- Male -
- Retrospective Studies -
- Surveys and Questionnaires -
- Treatment Outcome -
- Find related publications in this database (Keywords)
- acquired angioedema
- C1-inhibitor deficiency
- hereditary angioedema
- icatibant
- laryngeal edema
- observational study
- therapy