Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zollner-Schwetz, I; Leitner, E; Plieschnegger, W; Semlitsch, G; Stepan, V; Reiter, L; Reicht, G; Mörth, E; Pavek, J; Parsché, P; Betterklieber, C; Atzmüller, D; Krause, R; Högenauer, C.
Primary resistance of Helicobacter pylori is still low in Southern Austria.
Int J Med Microbiol. 2016; 306(4):206-211
Doi: 10.1016/j.ijmm.2016.04.003
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Zollner-Schwetz Ines
- Co-Autor*innen der Med Uni Graz
- Hoegenauer Christoph
- Krause Robert
- Leitner-Meyer Eva
- Stepan Vinzenz
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- Abstract:
- We determined primary and secondary resistance rates of H. pylori in different regions of Austria and potential bacterial and host factors associated with resistance. In a prospective multicentre study H. pylori was cultivated from biopsies and susceptibility testing was performed according to EUCAST. Resistance to clarithromycin and levofloxacin was determined by sequencing of the resistance-determining regions of 23S rRNA and gyrA genes. cagA, vacA and babA2 genotypes were determined. A total of 1266 patients were included. 178 isolates were cultured: 128 from patients without prior eradication therapy, 50 from patients after failed eradication. Primary resistance to clarithromycin, levofloxacin and metronidazole were 17.2%, 9.4% and 10.2%, respectively. Secondary resistance to clarithromycin, levofloxacin and metronidazole were 64%, 18% and 44%, respectively. Prior eradication was associated with a higher risk of clarithromycin as well as metronidazole resistance (OR=8.1; 95% CI 3.8-17.1 and OR 5.7; 95% CI 2.5-13, respectively). Primary resistance to both clarithromycin and levofloxacin was markedly lower in Southern Austria than recently reported. Copyright © 2016 Elsevier GmbH. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anti-Bacterial Agents - pharmacology
- Austria - epidemiology
- Clarithromycin - pharmacology
- DNA, Bacterial - chemistry
- DNA, Bacterial - genetics
- DNA, Ribosomal - chemistry
- DNA, Ribosomal - genetics
- Drug Resistance, Bacterial -
- Female -
- Genotype -
- Helicobacter Infections - epidemiology
- Helicobacter Infections - microbiology
- Helicobacter pylori - drug effects
- Helicobacter pylori - genetics
- Helicobacter pylori - isolation & purification
- Humans -
- Levofloxacin - pharmacology
- Male -
- Microbial Sensitivity Tests -
- Middle Aged -
- Prevalence -
- Prospective Studies -
- RNA, Ribosomal, 23S - genetics
- Sequence Analysis, DNA -
- Virulence Factors - genetics
- Find related publications in this database (Keywords)
- Helicobacter pylori
- Primary resistance
- Clarithromycin resistance
- Virulence factors
- Mutations 23S rRNA