Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Artinger, K; Kirsch, AH; Aringer, I; Moschovaki-Filippidou, F; Eller, P; Rosenkranz, AR; Eller, K.
Innate and adaptive immunity in experimental glomerulonephritis: a pathfinder tale.
Pediatr Nephrol. 2017; 32(6):943-947
Doi: 10.1007/s00467-016-3404-7
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- Führende Autor*innen der Med Uni Graz
- Aringer Ida
- Eller Kathrin
- Co-Autor*innen der Med Uni Graz
- Artinger Katharina
- Eller Philipp
- Kirsch Alexander
- Rosenkranz Alexander
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- Abstract:
- The role of innate and adaptive immune cells in the experimental model of nephrotoxic serum nephritis (NTS) has been rigorously studied in recent years. The model is dependent on kidney-infiltrating T helper (TH) 17 and TH1 cells, which recruit neutrophils and macrophages, respectively, and cause sustained kidney inflammation. In a later phase of disease, regulatory T cells (Tregs) infiltrate the kidney in an attempt to limit disease activity. In the early stage of NTS, lymph node drainage plays an important role in disease initiation since dendritic cells present the antigen to T cells in the T cell zones of the draining lymph nodes. This results in the differentiation and proliferation of TH17 and TH1 cells. In this setting, immune regulatory cells (Tregs), namely, CCR7-expressing Tregs and mast cells (MCs), which are recruited by Tregs via the production of interleukin-9, exert their immunosuppressive capacity. Together, these two cell populations inhibit T cell differentiation and proliferation, thereby limiting disease activity by as yet unknown mechanisms. In contrast, the spleen plays no role in immune activation in NTS, but constitutes a place of extramedullary haematopoiesis. The complex interactions of immune cells in NTS are still under investigation and might ultimately lead to targeted therapies in glomerulonephritis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptive Immunity -
- Animals -
- Cell Differentiation - immunology
- Cell Proliferation -
- Disease Models, Animal -
- Glomerulonephritis - immunology
- Humans -
- Immunity, Innate -
- Interleukin-9 - immunology
- Interleukin-9 - metabolism
- Kidney - immunology
- Lymph Nodes - immunology
- Mast Cells - immunology
- Mast Cells - metabolism
- Mice -
- Receptors, CCR7 - metabolism
- Spleen - immunology
- T-Lymphocytes, Regulatory - immunology
- T-Lymphocytes, Regulatory - metabolism
- Th1 Cells - immunology
- Th17 Cells - immunology
- Find related publications in this database (Keywords)
- Nephrotoxic serum nephritis
- Immune system
- T cell
- Regulatory T-cell
- Chemokines
- Lymph node