Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bosiers, M; Scheinert, D; Hendriks, JM; Wissgott, C; Peeters, P; Zeller, T; Brodmann, M; Staffa, R; TOBA investigators.
Results from the Tack Optimized Balloon Angioplasty (TOBA) study demonstrate the benefits of minimal metal implants for dissection repair after angioplasty.
J Vasc Surg. 2016; 64(1):109-116
Doi: 10.1016/j.jvs.2016.02.043
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Brodmann Marianne
- Study Group Mitglieder der Med Uni Graz:
- Eller Philipp
- Pilger Ernst
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The mechanism of angioplasty is disruption of atherosclerotic plaque, which often results in dissections. Dissection after percutaneous transluminal angioplasty (PTA) remains a significant clinical problem and untreated may cause acute occlusion or later restenosis. Stents are used to manage dissections, which is often followed by in-stent restenosis and occasionally stent fracture. Tack (Intact Vascular, Wayne, Pa) implants have minimal metal and low radial force and are specifically designed for dissection repair. This study evaluated Tack implants for treatment of dissections resulting from standard balloon PTA for femoral-popliteal arterial disease. Twelve-month outcomes after Tack treatment of post-PTA dissections are described. This prospective, single-arm study evaluated patients with ischemia (Rutherford clinical category 2-4) caused by lesions of the superficial femoral and popliteal arteries. Patients were treated with standard balloon angioplasty, and post-PTA dissections were treated with Tacks. The primary end points were core laboratory-adjudicated device technical success, defined as the ability of the Tack implants to resolve post-PTA dissection, and device safety, defined as the absence of new-onset major adverse events. Patients were followed up to 12 months after implantation. Tacks were used in 130 patients with post-PTA dissections (74.0% ≥ grade C). Technical success was achieved in 128 (98.5%) patients with no major adverse events at 30 days. The 12-month patency was 76.4%, and freedom from target lesion revascularization was 89.5%. Significant improvement from baseline was observed in Rutherford clinical category (82.8% with grade ≤1) and ankle-brachial index (0.68 ± 0.18 to 0.94 ± 0.15; P < .0001). Tack implant treatment of post-PTA dissection was safe, produced reasonable patency, and resulted in low rates of target lesion revascularization. Tack treatment represents a new, minimal metal paradigm for dissection repair that can safely improve the clinical results associated with PTA. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Angioplasty, Balloon - adverse effects
- Blood Vessel Prosthesis -
- Blood Vessel Prosthesis Implantation - adverse effects
- Blood Vessel Prosthesis Implantation - instrumentation
- Endovascular Procedures - adverse effects
- Endovascular Procedures - instrumentation
- Female -
- Femoral Artery - diagnostic imaging
- Femoral Artery - injuries
- Femoral Artery - physiopathology
- Humans -
- Lower Extremity - blood supply
- Male -
- Metals -
- Middle Aged -
- Peripheral Arterial Disease - diagnostic imaging
- Peripheral Arterial Disease - physiopathology
- Peripheral Arterial Disease - therapy
- Popliteal Artery - diagnostic imaging
- Popliteal Artery - injuries
- Popliteal Artery - physiopathology
- Prospective Studies -
- Prosthesis Design -
- Retreatment -
- Time Factors -
- Treatment Outcome -
- Vascular Patency -
- Vascular System Injuries - diagnostic imaging
- Vascular System Injuries - etiology
- Vascular System Injuries - therapy