Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wallner-Liebmann, S; Tenori, L; Mazzoleni, A; Dieber-Rotheneder, M; Konrad, M; Hofmann, P; Luchinat, C; Turano, P; Zatloukal, K.
Individual Human Metabolic Phenotype Analyzed by (1)H NMR of Saliva Samples.
J Proteome Res. 2016; 15(6):1787-1793
Doi: 10.1021/acs.jproteome.5b01060
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Holasek Sandra Johanna
- Zatloukal Kurt
- Co-authors Med Uni Graz
- Dieber-Rotheneder Martina
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- Abstract:
- Saliva is an important physiological fluid that contains a complex mixture of analytes that may produce a characteristic individual signature. In recent years, it has been demonstrated that urine possesses a clear signature of the individual metabolic phenotype. Here NMR-based metabolomics was employed to analyze saliva from 23 healthy volunteers. About six saliva samples were collected daily from each individual for 10 consecutive days: 7 days in a real-life situation (days 1-7, Phase I) and 3 days (days 8-10, Phase II) under a standardized diet plus a physical exercise program at day 10. The result is the first demonstration of the existence of an individual metabolic phenotype in saliva. A systematic comparative analysis with urine samples from the same collection scheme demonstrates that the individual phenotype in saliva is slightly weaker than that in urine but less influenced by diet.
- Find related publications in this database (using NLM MeSH Indexing)
- Diet -
- Exercise -
- Healthy Volunteers -
- Humans -
- Magnetic Resonance Spectroscopy -
- Metabolomics - methods
- Phenotype -
- Saliva - chemistry
- Saliva - metabolism
- Find related publications in this database (Keywords)
- saliva
- urine
- metabolomics
- NMR
- fingerprinting
- individual phenotype
- diet
- standardized lifestyle