Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Resch, B; Kurath-Koller, S; Hahn, J; Raith, W; Köstenberger, M; Gamillscheg, A.
Respiratory syncytial virus-associated hospitalizations over three consecutive seasons in children with congenital heart disease.
Eur J Clin Microbiol Infect Dis. 2016; 35(7):1165-1169
Doi: 10.1007/s10096-016-2649-1
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- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Gamillscheg Andreas
- Koestenberger Martin
- Kurath-Koller Stefan
- Raith Wolfgang
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- Abstract:
- The purpose of this investigation was to analyze the burden of respiratory syncytial virus (RSV)-related hospitalizations in infants and children with congenital heart disease (CHD) over three consecutive RSV seasons. Retrospectively, all children with hemodynamically significant (HS-CHD) and not significant (HNS-CHD) CHD born between 2004 and 2008 at a tertiary care university hospital and identified by ICD-10 diagnoses were included. Data on RSV-related hospitalizations over the first three years of life covering at least three RSV seasons (November-April) were analyzed. The overall incidence of RSV-related hospitalization was 9.6 % (58/602), without a statistically significant difference between HS-CHD and HNS-CHD (7.3 % vs. 10.4 %; p = 0.258). Recommendation of palivizumab prophylaxis did not influence the RSV hospitalization rates between groups. Patients with HS-CHD and early surgery were significantly less often hospitalized due to RSV compared to those with delayed surgery (1.3 % vs. 14.3 %; p = 0.003). The median duration of hospitalization was 8.5 days (HS-CHD: 14 vs. 7 days; p = 0.003). Thirteen patients (22.4 %) were admitted to the intensive care unit (ICU), for a median of 10 days. The median age at admission was 2 months, with a significant difference between HS-CHD and HNS-CHD (6 vs. 2 months; p = 0.001). The majority (97 %) of RSV-related hospitalizations occurred before 12 months of age. Patients with HS-CHD had a significantly more severe course of RSV disease and were older at the time of hospitalization. Early surgery seemed to significantly reduce the risk of RSV hospitalization during the first RSV season.
- Find related publications in this database (using NLM MeSH Indexing)
- Child, Preschool -
- Cost of Illness -
- Female -
- Follow-Up Studies -
- Heart Defects, Congenital - complications
- Heart Defects, Congenital - epidemiology
- Heart Defects, Congenital - therapy
- Hospitalization -
- Humans -
- Infant -
- Intensive Care Units -
- Male -
- Respiratory Syncytial Virus Infections - complications
- Respiratory Syncytial Virus Infections - epidemiology
- Respiratory Syncytial Virus Infections - therapy
- Respiratory Syncytial Virus, Human -
- Retrospective Studies -
- Risk Factors -
- Seasons -