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Silbernagel, G; Machann, J; Häring, HU; Fritsche, A; Peter, A.
Plasminogen activator inhibitor-1, monocyte chemoattractant protein-1, e-selectin and C-reactive protein levels in response to 4-week very-high-fructose or -glucose diets.
Eur J Clin Nutr. 2014; 68(1):97-100 Doi: 10.1038/ejcn.2013.228 [OPEN ACCESS]
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Leading authors Med Uni Graz: Silbernagel Günther
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Abstract:: High intake of added sweeteners is considered to have a causal role in the pathogenesis of cardiometabolic disorders. Especially, high-fructose intake is regarded as potentially harmful to cardiometabolic health. It may cause not only weight gain but also low-grade inflammation, which represents an independent risk factor for developing type 2 diabetes and cardiovascular disease. In particular, fructose has been suggested to induce plasminogen activator inhibitor-1 (PAI-1) expression in the liver and to increase circulating inflammatory cytokines. We therefore aimed to investigate, whether high-fructose diet has an impact on PAI-1, monocyte chemoattractant protein-1 (MCP-1), e-selectin and C-reactive protein (CRP) concentrations in healthy humans. We studied 20 participants (12 males and 8 females) of the TUebingen FRuctose Or Glucose study. This is an exploratory, parallel, prospective, randomized, single-blinded, outpatient, hypercaloric, intervention study. The participants had a mean age of 30.9 ± 2.1 years and a mean body mass index of 26.0 ± 0.5 kg/m(2) and they received 150 g of either fructose or glucose per day for 4 weeks. There were neither significant changes of PAI-1, MCP-1, e-selectin and CRP after fructose (n=10) and glucose (n=10) intervention nor treatment effects (all P>0.2). Moreover, we did not observe longitudinal associations of the inflammatory parameters with triglycerides, liver fat, visceral fat and body weight in the fructose group. Temporary high-fructose intake does not seem to cause inflammation in apparently healthy people in this secondary analysis of a small feeding trial.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Body Mass Index -; Body Weight -; C-Reactive Protein - metabolism; Chemokine CCL2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diet -; E-Selectin - blood; Female -; Fructose - administration & dosage Fructose - adverse effects; Glucose - administration & dosage Glucose - adverse effects; Humans -; Inflammation - chemically induced; Intra-Abdominal Fat - metabolism; Liver - metabolism; Male -; Nutritive Sweeteners - administration & dosage Nutritive Sweeteners - adverse effects; Plasminogen Activator Inhibitor 1 - blood; Prospective Studies -; Single-Blind Method -; Triglycerides - blood
Find related publications in this database (Keywords): CRP; E-selectin; fructose; inflammation; MCP-1; PAI-1