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SHR Neuro Cancer Cardio Lipid Metab Microb
Engelberger, RP; Limacher, A; Kucher, N; Baumann, F; Silbernagel, G; Benghozi, R; Do, DD; Willenberg, T; Baumgartner, I.
Biological variation of established and novel biomarkers for atherosclerosis: Results from a prospective, parallel-group cohort study.
Clin Chim Acta. 2015; 447(21): 16-22.
Doi: 10.1016/j.cca.2015.05.003
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PubMed
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- Co-authors Med Uni Graz
- Silbernagel Günther
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- Abstract:
- Biomarkers are a promising tool for the management of patients with atherosclerosis, but their variation is largely unknown. We assessed within-subject and between-subject biological variation of biomarkers in peripheral artery disease (PAD) patients and healthy controls, and defined which biomarkers have a favorable variation profile for future studies. Prospective, parallel-group cohort study, including 62 patients with stable PAD (79% men, 65±7years) and 18 healthy control subjects (44% men, 57±7years). Blood samples were taken at baseline, and after 3-, 6-, and 12-months. We calculated within-subject (CVI) and between-subject (CVG) coefficients of variation and intra-class correlation coefficient (ICC). Mean levels of D-dimer, hs-CRP, IL-6, IL-8, MMP-9, MMP-3, S100A8/A9, PAI-1, sICAM-1, and sP-selectin levels were higher in PAD patients than in healthy controls (P≤.05 for all). CVI and CVG of the different biomarkers varied considerably in both groups. An ICC≥0.5 (indicating moderate-to-good reliability) was found for hs-CRP, D-Dimer, E-selectin, IL-10, MCP-1, MMP-3, oxLDL, sICAM-1 and sP-selectin in both groups, for sVCAM in healthy controls and for MMP-9, PAI-1 and sCD40L in PAD patients. Single biomarker measurements are of limited utility due to large within-subject variation, both in PAD patients and healthy subjects. D-dimer, hs-CRP, MMP-9, MMP-3, PAI-1, sP-selectin and sICAM-1 are biomarkers with both higher mean levels in PAD patients and a favorable variation profile making them most suitable for future studies. Copyright © 2015 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Biomarkers - blood
- Case-Control Studies -
- Cohort Studies -
- Female -
- Humans -
- Male -
- Middle Aged -
- Peripheral Arterial Disease - blood
- Prospective Studies -
- Find related publications in this database (Keywords)
- Atherosclerosis
- Biomarkers
- Inflammation
- Peripheral vascular disease
- Biological variation