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SHR Neuro Cancer Cardio Lipid Metab Microb
Wyss, TR; Adam, L; Haynes, AG; Kucher, N; Silbernagel, G; Do, DD; Schmidli, J; Baumgartner, I.
Impact of cardiovascular risk factors on severity of peripheral artery disease.
Atherosclerosis. 2015; 242(1):97-101
Doi: 10.1016/j.atherosclerosis.2015.07.002
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- Co-authors Med Uni Graz
- Silbernagel Günther
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- Abstract:
- The development of peripheral artery disease is affected by the presence of cardiovascular risk factors. It is unclear, whether particular risk factors are leading to different clinical stages of peripheral artery disease. The aim of this retrospective cross-sectional study was to assess the association of cardiovascular risk factors with the presence of critical limb ischaemia. The study cohort was derived from a consecutive registry of patients undergoing endovascular therapy in a tertiary referral centre between January 2000 and April 2014. Patients undergoing first-time endovascular intervention for chronic peripheral artery disease of the lower extremities were included. Univariate and multivariate logistic regression models were used to assess the association of age, sex, diabetes mellitus, hypertension, dyslipidaemia, smoking, and renal insufficiency with critical limb ischaemia vs. intermittent claudication. A total of 3406 patients were included in the study (mean age 71.7 ± 11.8 years, 2075 [61%] male). There was a significant association of age (OR 1.67, 95%-CI 1.53-1.82, p < 0.001), male gender (OR 1.23, 95%-CI 1.04-1.47, p = 0.016), diabetes (OR 1.99, 95%-CI 1.68-2.36, p < 0.001) and renal insufficiency (OR 1.62, 95%-CI 1.35-1.96, p < 0.001) with the likelihood of critical limb ischaemia. Smoking was associated with intermittent claudication rather than critical limb ischaemia (OR 0.78, 95%-CI 0.65-0.94, p = 0.010), while hypertension and dyslipidaemia did not show an association with critical limb ischaemia. In peripheral artery disease patients undergoing first-time endovascular treatment, age, male gender, diabetes, and renal insufficiency were the strongest predictors for the presence of critical limb ischaemia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Aged -
- Aged, 80 and over -
- Cardiovascular Diseases - epidemiology
- Diabetes Mellitus - epidemiology
- Dyslipidemias - epidemiology
- Endovascular Procedures -
- Female -
- Humans -
- Hypertension - epidemiology
- Intermittent Claudication - epidemiology
- Ischemia - epidemiology
- Leg - blood supply
- Male -
- Middle Aged -
- Peripheral Arterial Disease - epidemiology
- Peripheral Arterial Disease - surgery
- Renal Insufficiency, Chronic - epidemiology
- Risk Factors -
- Severity of Illness Index -
- Sex Factors -
- Smoking - epidemiology
- Find related publications in this database (Keywords)
- Peripheral artery disease
- Diabetic vascular disease
- Age
- Diabetes mellitus
- Renal insufficiency