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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Donnerer, J; Liebmann, I.
Interaction of αβ-Methylene ATP with the Cholinergic Twitch Response in the Guinea-Pig Ileum.
Pharmacology. 2016; 97(5-6):277-281
Doi: 10.1159/000444504
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Donnerer Josef
- Co-authors Med Uni Graz
- Liebmann Ingrid
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- Abstract:
- In this study, direct effects of the P2X purinoceptor agonist αβ-methylene ATP (αβ-meATP) and effects on the cholinergic twitch response of the electrically stimulated longitudinal muscle-myenteric plexus (LMMP) strip of the guinea-pig ileum, were investigated. αβ-meATP (1, 3, and 10 µmol/l) induced short-lasting contractions on its own, followed by an inhibition of the twitch response during its presence in the organ bath. The inhibitor of small conductance Ca2+-activated K+ (SK) channels, apamin (100 nmol/l), prevented the inhibitory effect of αβ-meATP on the twitch response, whereas tetraethylammonium (300 µmol/l), a blocker of voltage-gated K+ channels and an inhibitor at nicotinic acetylcholine receptors, augmented the inhibitory effect of αβ-meATP on the twitch response. It is concluded, that there is a functional interaction between P2X receptors and nicotinic receptors in the LMMP strip, and that a major part of the excitatory input to the cholinergic motor neuron evoking the twitch response is purinergic and not nicotinergic. © 2016 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - analogs & derivatives
- Adenosine Triphosphate - pharmacology
- Animals -
- Apamin - pharmacology
- Guinea Pigs -
- Ileum - drug effects
- Ileum - physiology
- Male -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Nicotinic Antagonists - pharmacology
- Potassium Channel Blockers - pharmacology
- Purinergic P2X Receptor Agonists - pharmacology
- Receptors, Purinergic P2X - physiology
- Tetraethylammonium - pharmacology
- Find related publications in this database (Keywords)
- Guinea-pig ileum
- Longitudinal muscle-myenteric plexus strip
- alpha beta-Methylene ATP
- Potassium channel blockers
- Cholinergic twitch response