Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Enko, D; Kriegshäuser, G; Stolba, R; Mangge, H; Brandstetter, D; Mayr, N; Forstner, T; Halwachs-Baumann, G.
Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.
Eur J Clin Nutr. 2016; 70(9):1000-1003
Doi: 10.1038/ejcn.2016.66
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Enko Dietmar
- Co-Autor*innen der Med Uni Graz
- Baumann Gabriele
- Kriegshäuser Gernot
- Mangge Harald
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- Abstract:
- Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxy-vitamin D (25(OH)D) status and serum CrossLaps levels in individuals with PALM and normal controls. All participants (n=210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH)D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined. Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH)D (mean: 24.95±10.04 vs 28.59±9.56 ng/ml, P=0.018) and higher CrossLaps serum levels (mean: 0.46±0.31 vs 0.43±0.49 ng/ml, P=0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero- or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls. Individuals with PALM were found to have lower 25(OH)D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH)D and CrossLaps serum measurements should be performed in individuals with PALM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Body Mass Index -
- Collagen - blood
- Collagen Type I - blood
- Female -
- Genotype -
- Humans -
- Intestinal Absorption -
- Lactase - blood
- Lactase - deficiency
- Lactase - genetics
- Lactase - metabolism
- Lactose - metabolism
- Lactose Intolerance - blood
- Lactose Intolerance - complications
- Lactose Intolerance - genetics
- Male -
- Middle Aged -
- Osteoporosis - etiology
- Osteoporosis - genetics
- Peptide Fragments - blood
- Peptides - blood
- Polymorphism, Single Nucleotide -
- Prospective Studies -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D Deficiency - blood
- Vitamin D Deficiency - complications
- Vitamins - blood
- Young Adult -