Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Foris, V; Kovacs, G; Marsh, LM; Bálint, Z; Tötsch, M; Avian, A; Douschan, P; Ghanim, B; Klepetko, W; Olschewski, A; Olschewski, H.
CD133+ cells in pulmonary arterial hypertension.
Eur Respir J. 2016; 48(2):459-469
Doi: 10.1183/13993003.01523-2015
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- Führende Autor*innen der Med Uni Graz
- Foris Vasile
- Olschewski Horst
- Co-Autor*innen der Med Uni Graz
- Avian Alexander
- Balint Zoltan
- Douschan Philipp
- Kovacs Gabor
- Marsh Leigh
- Olschewski Andrea
- Tötsch Martin
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- Abstract:
- Circulating mononuclear cells may play an important role for the vascular remodelling in pulmonary arterial hypertension (PAH), but studies addressing multiple progenitor populations are rare and inconsistent.We used a comprehensive fluorescence-activated cell sorting analysis of circulating mononuclear cells in 20 PAH patients and 20 age- and sex-matched controls, and additionally analysed CD133(+) cells in the lung tissue of five PAH transplant recipients and five healthy controls (donor lungs).PAH patients were characterised by increased numbers of circulating CD133(+) cells and lymphopenia as compared with control. In PAH, CD133(+) subpopulations positive for CD117 or CD45 were significantly increased, whereas CD133(+)CD309(+), CD133(+)CXCR2(+) and CD133(+)CD31(+) cells were decreased. In CD133(+) cells, SOX2, Nanog, Ki67 and CXCR4 were not detected, but Oct3/4 mRNA was present in both PAH and controls. In the lung tissue, CD133(+) cells included three main populations: type 2 pneumocytes, monocytes and undifferentiated cells without significant differences between PAH and controls.In conclusion, circulating CD133(+) progenitor cells are elevated in PAH and consist of phenotypically different subpopulations that may be up- or downregulated. This may explain the inconsistent results in the literature. CD133(+) type 2 pneumocytes in the lung tissue are not associated with circulating CD133(+) mononuclear cells. Copyright ©ERS 2016.
- Find related publications in this database (using NLM MeSH Indexing)
- AC133 Antigen - metabolism
- Adult -
- Aged -
- Aged, 80 and over -
- Cell Separation -
- Female -
- Flow Cytometry -
- Humans -
- Hypertension, Pulmonary - metabolism
- Leukocyte Common Antigens - metabolism
- Leukocytes, Mononuclear - metabolism
- Lung - pathology
- Male -
- Middle Aged -
- Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
- Proto-Oncogene Proteins c-kit - metabolism
- Pulmonary Artery - pathology
- Receptors, Interleukin-8B - metabolism
- SOXB1 Transcription Factors - metabolism
- Stem Cells -
- Vascular Remodeling -
- Young Adult -