Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Blank, DA; Hooper, SB; Binder-Heschl, C; Kluckow, M; Gill, AW; LaRosa, DA; Inocencio, IM; Moxham, A; Rodgers, K; Zahra, VA; Davis, PG; Polglase, GR.
Lung ultrasound accurately detects pneumothorax in a preterm newborn lamb model.
J Paediatr Child Health. 2016; 52(6):643-648
Doi: 10.1111/jpc.13154
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Binder-Heschl Corinna
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Pneumothorax is a common emergency affecting extremely preterm. In adult studies, lung ultrasound has performed better than chest x-ray in the diagnosis of pneumothorax. The purpose of this study was to determine the efficacy of lung ultrasound (LUS) examination to detect pneumothorax using a preterm animal model. This was a prospective, observational study using newborn Border-Leicester lambs at gestational age = 126 days (equivalent to gestational age = 26 weeks in humans) receiving mechanical ventilation from birth to 2 h of life. At the conclusion of the experiment, LUS was performed, the lambs were then euthanised and a post-mortem exam was immediately performed. We used previously published ultrasound techniques to identify pneumothorax. Test characteristics of LUS to detect pneumothorax were calculated, using the post-mortem exam as the 'gold standard' test. Nine lambs (18 lungs) were examined. Four lambs had a unilateral pneumothorax, all of which were identified by LUS with no false positives. This was the first study to use post-mortem findings to test the efficacy of LUS to detect pneumothorax in a newborn animal model. Lung ultrasound accurately detected pneumothorax, verified by post-mortem exam, in premature, newborn lambs. © 2016 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autopsy -
- Humans -
- Lung -
- Pneumothorax - diagnostic imaging
- Prospective Studies -
- Sheep -
- Ultrasonography -
- Find related publications in this database (Keywords)
- bubble test
- lung aeration
- lung injury
- post-mortem exam
- respiratory distress syndrome