Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Thonhofer, M; Weber, P; Gonzalez Santana, A; Tysoe, C; Fischer, R; Pabst, BM; Paschke, E; Schalli, M; Stütz, AE; Tschernutter, M; Windischhofer, W; Withers, SG.
Synthesis of C-5a-substituted derivatives of 4-epi-isofagomine: notable β-galactosidase inhibitors and activity promotors of GM1-gangliosidosis related human lysosomal β-galactosidase mutant R201C.
Carbohydr Res. 2016; 429(15):71-80
Doi: 10.1016/j.carres.2016.03.020
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Pabst Bettina
- Paschke Eduard
- Schalli Michael
- Tschernutter Marion
- Windischhofer Werner
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- Abstract:
- From an easily available partially protected analog of 1-deoxy-L-gulo-nojirimycin, by chain-branching at C-4 and suitable modification, lipophilic analogs of the powerful β-D-galactosidase inhibitor 4-epi-isofagomine have been prepared. New compounds exhibit considerably improved inhibitory activities when compared with the unsubstituted parent compound and may serve as leads toward new pharmacological chaperones for GM1-gangliosidosis and Morquio B disease. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-Deoxynojirimycin - analogs & derivatives
- 1-Deoxynojirimycin - chemistry
- Gangliosidosis, GM1 - drug therapy
- Humans -
- Hydrophobic and Hydrophilic Interactions -
- Imino Pyranoses - chemical synthesis
- Imino Pyranoses - chemistry
- Mucopolysaccharidosis IV - drug therapy
- beta-Galactosidase - antagonists & inhibitors
- beta-Galactosidase - chemistry
- Find related publications in this database (Keywords)
- Iminoalditol
- 4-Epi-isofagomine
- Galactosidase inhibitor
- Pharmacological chaperone
- G(M1)-gangliosidosis