Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vanstraelen, K; Prattes, J; Maertens, J; Lagrou, K; Schoemans, H; Peersman, N; Vermeersch, P; Theunissen, K; Mols, R; Augustijns, P; Annaert, P; Hoenigl, M; Spriet, I.
Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.
Eur J Clin Pharmacol. 2016; 72(8):953-963
Doi: 10.1007/s00228-016-2057-6
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- Führende Autor*innen der Med Uni Graz
- Prattes Jürgen
- Co-Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- Low posaconazole plasma concentrations (PPCs) are frequently encountered in allogeneic hematopoietic stem cell transplant (HSCT) patients, due to variable gastrointestinal absorption. In this study, the impact of intestinal mucositis on posaconazole exposure is investigated. A prospective pharmacokinetic study was performed including allogeneic HSCT patients receiving posaconazole prophylaxis with the oral suspension or tablets. Steady state PPCs were determined using high-performance liquid chromatography-fluorescence detection at the day of transplantation (=day 0), day +7, and +14. Citrulline was measured using liquid chromatography-tandem mass spectrometry to evaluate severity of mucositis, at baseline (day -7 or -6), and at day 0, +7 and +14. Additionally, citrulline plasma concentrations and steady state trough PPCs were determined in hematological patients without HSCT or mucositis. Thirty-four HSCT patients received posaconazole oral suspension together with 25 cL of Coca Cola, 6 HSCT patients received posaconazole tablets and 33 hematological patients not receiving HSCT received posaconazole oral suspension. The median (interquartile range) average PPC was 0.26 mg/L (0.17-0.43), 0.67 mg/L (0.27-1.38), and 1.08 mg/L (0.96-1.38), with suspension in HSCT patients, suspension in hematological patients and tablets in HSCT patients, respectively. A higher trough PPC was encountered with the oral suspension when citrulline plasma concentrations were above 10 μmol/L compared to values below 10 μmol/L (p < 0.001), whereas for tablets, average PPCs remained high with citrulline plasma concentrations below or above 10 μmol/L (p = 0.64). Posaconazole tablets should be preferred to suspension in HSCT patients immediately after transplantation to prevent insufficient plasma exposure due to intestinal mucositis.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Antifungal Agents - administration & dosage
- Antifungal Agents - blood
- Antifungal Agents - pharmacokinetics
- Citrulline - blood
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Intestinal Mucosa -
- Male -
- Middle Aged -
- Mucositis - blood
- Mucositis - chemically induced
- Mycoses - prevention & control
- Suspensions -
- Tablets -
- Triazoles - administration & dosage
- Triazoles - blood
- Triazoles - pharmacokinetics
- Find related publications in this database (Keywords)
- Allogeneic HSCT
- Posaconazole oral suspension
- Posaconazole tablet
- Mucositis
- Citrulline