Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wölfler, MM; Küppers, M; Rath, W; Buck, VU; Meinhold-Heerlein, I; Classen-Linke, I.
Altered expression of progesterone receptor isoforms A and B in human eutopic endometrium in endometriosis patients.
Ann Anat. 2016; 206(10):1-6
Doi: 10.1016/j.aanat.2016.03.004
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Wölfler Monika Martina
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Recent data implicate an altered expression of progesterone receptor isoform A (PR-A) and B (PR-B) in the endometrium of endometriosis patients. This prospective exploratory study aimed to precisely determine the PR-A and PR-B expression using immunohistochemical techniques in eutopic endometrium of women with endometriosis compared with disease-free women throughout the menstrual cycle. All symptomatic patients underwent laparoscopy for the diagnosis of endometriosis and histological confirmation of the disease (EO) whereas controls were proven disease-free (CO). In CO samples (n=10) an increased expression of PR-A and PR-B during the proliferative to early secretory phase and a decreased expression of both receptor isoforms during the mid to late secretory phase was ascertained in accordance with previous studies. In patients with endometriosis (n=16) no cycle dependent pattern of PR-A and PR-B expression was identified in contrast to patients without endometriosis. Moreover, in EO samples a huge variety of inter- and intra-individual differences in PR-A and PR-B expression were detected. These data provide further evidence that dysregulation of the PR-A and PR-B expression might contribute to the pathophysiology of endometriosis. Copyright © 2016 Elsevier GmbH. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Endometriosis - metabolism
- Endometrium - metabolism
- Female -
- Gene Expression Regulation -
- Humans -
- Menstrual Cycle - metabolism
- Middle Aged -
- Receptors, Progesterone - metabolism
- Tissue Distribution -
- Young Adult -
- Find related publications in this database (Keywords)
- Endometriosis
- Eutopic endometrium
- PR-A/PR-B
- Immunohistochemistry
- Menstrual cycle