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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kluk, J; Kai, A; Koch, D; Taibjee, SM; O'Connor, S; Persic, M; Morris, S; Whittaker, S; Cerroni, L; Kempf, W; Petrella, T; Robson, A.
Indolent CD8-positive lymphoid proliferation of acral sites: three further cases of a rare entity and an update on a unique patient.
J Cutan Pathol. 2016; 43(2):125-136
Doi: 10.1111/cup.12633
(- Case Report)
Web of Science
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Primary cutaneous indolent CD8-positive lymphoid proliferation is an emerging entity characterized by slowly enlarging papules and nodules that are pathologically comprised of clonal nonepidermotropic medium-sized atypical CD8(+) T-cells. Although the majority of lesions are solitary and located on the ears, bilateral symmetrical presentations have been described and lesions may arise at other peripheral or 'acral' sites. Patients follow a benign clinical course and systemic involvement has not yet been observed. Despite this, some medical practitioners classify such lesions as peripheral T-cell lymphoma, NOS, a category implying aggressive disease. We present three cases seen in our institutions and provide an update on a previously reported unique patient who continues to develop recurrent and multifocal skin lesions. Systemic disease progression has not been observed, even in the presence of recurrent and multifocal cutaneous disease. Indolent CD8-positive lymphoid proliferation of acral sites is a distinctive and readily identifiable entity and should be included in the next consensus revision of cutaneous lymphoma classification. Although cases described thus far have followed an indolent clinical course, dermatologists should remain guarded about the prognosis and full staging and longitudinal observation are recommended until this condition is better understood. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- CD8-Positive T-Lymphocytes - metabolism
- CD8-Positive T-Lymphocytes - pathology
- Cell Proliferation -
- Female -
- Humans -
- Lymphoma, T-Cell, Cutaneous - metabolism
- Lymphoma, T-Cell, Cutaneous - pathology
- Lymphoma, T-Cell, Peripheral - metabolism
- Lymphoma, T-Cell, Peripheral - pathology
- Male -
- Middle Aged -
- Skin Neoplasms - metabolism
- Skin Neoplasms - pathology
- Find related publications in this database (Keywords)
- acral
- CD8
- indolent
- lymphoid proliferation
- lymphoma