Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Sóki, J; Edwards, R; Hedberg, M; Fang, H; Nagy, E; Nord, CE; ESCMID Study Group on Antimicrobial Resistance in Anaerobic Bacteria.
Examination of cfiA-mediated carbapenem resistance in Bacteroides fragilis strains from a European antibiotic susceptibility survey.
Int J Antimicrob Agents. 2006; 28(6): 497-502.
Doi: 10.1016/j.ijantimicag.2006.07.021
Web of Science
PubMed
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- Study Group Mitglieder der Med Uni Graz:
- Feierl Gebhard
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- Abstract:
- Of 1284 Bacteroides strains collected in Europe in 2000 for antibiotic susceptibility surveillance, 65 isolates displayed imipenem minimum inhibitory concentrations (MICs) > or =1 mg/L and were chosen for a thorough analysis of their resistance mechanism. Twenty-five of the isolates were positive for the cfiA carbapenem resistance gene. The resistance rates were 0.8% and 1.3% for imipenem and meropenem, respectively. In six of the strains, insertion sequence (IS) elements (IS613, IS614B, IS1186 and IS1187) activated the cfiA gene. However, other strains displayed at least elevated carbapenem MICs or were carbapenem resistant and produced measurable carbapenemase activities but did not harbour IS elements in the region upstream of the cfiA gene. The major determinant of carbapenem resistance in Bacteroides fragilis is production of CfiA metallo-beta-lactamase via activation of the cfiA gene by IS elements (higher level resistance) or by activation of its putative own promoter.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - pharmacology
- Bacterial Proteins - genetics Bacterial Proteins - metabolism
- Bacteroides Infections - epidemiology Bacteroides Infections - microbiology
- Bacteroides fragilis - drug effects Bacteroides fragilis - genetics
- Base Sequence -
- Carbapenems - pharmacology
- DNA Transposable Elements -
- Drug Resistance, Bacterial - genetics
- Drug Resistance, Bacterial - epidemiology
- Humans -
- Imipenem -
- Microbial Sensitivity Tests -
- Molecular Sequence Data -
- Polymerase Chain Reaction -
- Population Surveillance -
- Thienamycins -
- beta-Lactamases - genetics beta-Lactamases - metabolism
- Find related publications in this database (Keywords)
- cfiA
- Bacteroides fragilis
- imipenem
- meropenem
- insertion sequence (IS) elements