Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bainschab, A; Quehenberger, F; Greinix, HT; Krause, R; Wölfler, A; Sill, H; Zebisch, A.
Infections in patients with acute myeloid leukemia treated with low-intensity therapeutic regimens: Risk factors and efficacy of antibiotic prophylaxis.
Leuk Res. 2016; 42(3):47-51
Doi: 10.1016/j.leukres.2016.01.014
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Zebisch Armin
- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
- Krause Robert
- Quehenberger Franz
- Sill Heinz
- Wölfler Albert
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- Abstract:
- Survival of acute myeloid leukemia (AML) patients, who are unfit for high-dose chemotherapy, has significantly improved with the advent of low-intensity therapeutic regimens (LITR, comprising decitabine, azacitidine, and low-dose cytarabine). However, infectious complications are common during LITR treatment and might hamper the beneficial effect of these drugs. In this study, we aimed to evaluate the incidence of and predisposing risk factors for infections during LITR treatment of AML, as well as the value of antibiotic prophylaxis within this setting. Therefore, we retrospectively analyzed 40 AML patients, treated with 215 cycles of LITR and analyzed putative risk factors by multivariate logistic regression. Infections occurred in 53/215 (25%) of LITR cycles, resulting in death in six patients. Of the parameters assessed at the start of each LITR cycle, transfusion dependence (p=0.008) and increased LDH (p=0.027) independently predicted the occurrence of infection. Most importantly, however, antibiotic prophylaxis was independently associated with a decreased rate of infectious complications (p=0.030). It was regularly performed in neutropenic patients and even managed to eliminate low neutrophil counts as risk factor in multivariate models. These data argue for the efficacy of antibiotic prophylaxis during LITR therapy of AML and suggest its further evaluation within a prospective clinical trial. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antibiotic Prophylaxis - methods
- Antimetabolites, Antineoplastic - administration & dosage
- Antimetabolites, Antineoplastic - adverse effects
- Azacitidine - administration & dosage
- Azacitidine - adverse effects
- Azacitidine - analogs & derivatives
- Bacterial Infections - etiology
- Bacterial Infections - prevention & control
- Cytarabine - administration & dosage
- Cytarabine - adverse effects
- Decitabine -
- Female -
- Humans -
- Leukemia, Myeloid, Acute - drug therapy
- Male -
- Middle Aged -
- Retrospective Studies -
- Risk Factors -
- Virus Diseases - etiology
- Virus Diseases - prevention & control
- Find related publications in this database (Keywords)
- Acute myeloid leukemia
- Low-intensity treatment regimen
- Infection
- Antibiotic prophylaxis