Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Matuszak, J; Baumgartner, J; Zaloga, J; Juenet, M; da Silva, AE; Franke, D; Almer, G; Texier, I; Faivre, D; Metselaar, JM; Navarro, FP; Chauvierre, C; Prassl, R; Dézsi, L; Urbanics, R; Alexiou, C; Mangge, H; Szebeni, J; Letourneur, D; Cicha, I.
Nanoparticles for intravascular applications: physicochemical characterization and cytotoxicity testing.
Nanomedicine (Lond). 2016; 11(6):597-616
Doi: 10.2217/nnm.15.216
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- Co-authors Med Uni Graz
- Almer Gunter
- Mangge Harald
- Prassl Ruth
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- Abstract:
- We report the physicochemical analysis of nanosystems intended for cardiovascular applications and their toxicological characterization in static and dynamic cell culture conditions. Size, polydispersity and ζ-potential were determined in 10 nanoparticle systems including liposomes, lipid nanoparticles, polymeric and iron oxide nanoparticles. Nanoparticle effects on primary human endothelial cell viability were monitored using real-time cell analysis and live-cell microscopy in static conditions, and in a flow model of arterial bifurcations. The majority of tested nanosystems were well tolerated by endothelial cells up to the concentration of 100 μg/ml in static, and up to 400 μg/ml in dynamic conditions. Pilot experiments in a pig model showed that intravenous administration of liposomal nanoparticles did not evoke the hypersensitivity reaction. These findings are of importance for future clinical use of nanosystems intended for intravascular applications.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cell Survival - drug effects
- Endothelial Cells - cytology
- Endothelial Cells - drug effects
- Ferric Compounds - chemistry
- Ferric Compounds - toxicity
- Human Umbilical Vein Endothelial Cells -
- Humans -
- Liposomes - chemistry
- Liposomes - toxicity
- Male -
- Nanoparticles - chemistry
- Nanoparticles - toxicity
- Polymers - chemistry
- Polymers - toxicity
- Swine -
- Find related publications in this database (Keywords)
- atherosclerosis
- endothelial cells
- hypersensitivity reaction
- live-cell analysis
- nanoparticle biocompatibility
- nanoparticle stability