Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hoenigl, M; de Oliveira, MF; Pérez-Santiago, J; Zhang, Y; Morris, S; McCutchan, AJ; Finkelman, M; Marcotte, TD; Ellis, RJ; Gianella, S.
(1→3)-β-D-Glucan Levels Correlate With Neurocognitive Functioning in HIV-Infected Persons on Suppressive Antiretroviral Therapy: A Cohort Study.
Medicine (Baltimore). 2016; 95(11):e3162-e3162
Doi: 10.1097/MD.0000000000003162
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
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- Abstract:
- Microbial translocation from the gut is associated with immune dysfunction, persistent inflammation, and likely plays a role in the pathogenesis of neurocognitive dysfunction during HIV infection. (1→3)-β-D-Glucan (BDG) is a component of most fungal cell walls and might be a useful indicator of gut mucosal barrier impairment. The objective of this study was to evaluate whether higher blood BDG levels correlate with impaired neurocognitive functioning in a cohort of HIV-infected adults with suppressed levels of HIV RNA in blood plasma. In this cross-sectional cohort study, we measured levels of BDG in blood plasma and cerebrospinal fluid (CSF) supernatant samples in a cohort of adults with acute/early HIV infection, who initiated antiretroviral therapy (ART) during the earliest phase of infection and achieved suppressed levels of HIV RNA in blood plasma (<50 copies/mL) thereafter. We compared BDG with established biomarkers of microbial translocation, immune activation, and cognitive dysfunction (evaluated by global deficit score). We found that higher blood BDG levels were significantly related to higher global deficit scores, reflecting worse neurocognitive performance (Spearman r = 0.47; P = 0.042) among HIV-infected adults with suppressed viral loads who initiated ART early in infection. Two CSF samples presented elevated BDG levels. Interestingly, these 2 samples originated from the 2 subjects with the highest global deficit scores of the cohort. BDG may be a promising independent biomarker associated with neurocognitive functioning in virologically suppressed HIV-infected individuals.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Anti-HIV Agents - therapeutic use
- Bacterial Translocation -
- Biomarkers - blood
- Biomarkers - cerebrospinal fluid
- CD4 Lymphocyte Count -
- Cognition Disorders - blood
- Cognition Disorders - cerebrospinal fluid
- Cross-Sectional Studies -
- Female -
- HIV -
- HIV Infections - blood
- HIV Infections - cerebrospinal fluid
- HIV Infections - drug therapy
- Humans -
- Interleukin-8 - blood
- Interleukin-8 - cerebrospinal fluid
- Lipopolysaccharide Receptors - blood
- Lipopolysaccharide Receptors - cerebrospinal fluid
- Male -
- Middle Aged -
- Neuropsychological Tests -
- RNA, Viral - blood
- Retrospective Studies -
- Severity of Illness Index -
- beta-Glucans - blood
- beta-Glucans - cerebrospinal fluid