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SHR Neuro Cancer Cardio Lipid Metab Microb
Ruan, Y; Thabit, H; Leelarathna, L; Hartnell, S; Willinska, ME; Dellweg, S; Benesch, C; Mader, JK; Holzer, M; Kojzar, H; Evans, ML; Pieber, TR; Arnolds, S; Hovorka, R; AP@home Consortium.
Variability of Insulin Requirements Over 12 Weeks of Closed-Loop Insulin Delivery in Adults With Type 1 Diabetes.
Diabetes Care. 2016; 39(5):830-832
Doi: 10.2337/dc15-2623
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- Co-authors Med Uni Graz
- Holzer Manuel
- Kojzar Harald
- Mader Julia
- Pieber Thomas
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- Abstract:
- To quantify variability of insulin requirements during closed-loop insulin delivery. We retrospectively analyzed overnight, daytime, and total daily insulin amounts delivered during a multicenter closed-loop trial involving 32 adults with type 1 diabetes. Participants applied hybrid day-and-night closed-loop insulin delivery under free-living home conditions over 12 weeks. The coefficient of variation was adopted to measure variability of insulin requirements in individual subjects. Data were analyzed from 1,918 nights, 1,883 daytime periods and 1,564 total days characterized by closed-loop use over 85% of time. Variability of overnight insulin requirements (mean [SD] coefficient of variation 31% [4]) was nearly twice as high as variability of total daily requirements (17% [3], P < 0.001) and was also higher than variability of daytime insulin requirements (22% [4], P < 0.001). Overnight insulin requirements were significantly more variable than daytime and total daily amounts. This may explain why some people with type 1 diabetes report frustrating variability in morning glycemia. © 2016 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
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- Humans -
- Hypoglycemic Agents - administration & dosage
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