Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Hoenigl, M; Chaillon, A; Kessler, HH; Haas, B; Stelzl, E; Weninger, K; Little, SJ; Mehta, SR.
Characterization of HIV Transmission in South-East Austria.
PLoS One. 2016; 11(3):e0151478-e0151478
Doi: 10.1371/journal.pone.0151478
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Kessler Harald
- Co-Autor*innen der Med Uni Graz
- Stelzl Evelyn
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- Abstract:
- To gain deeper insight into the epidemiology of HIV-1 transmission in South-East Austria we performed a retrospective analysis of 259 HIV-1 partial pol sequences obtained from unique individuals newly diagnosed with HIV infection in South-East Austria from 2008 through 2014. After quality filtering, putative transmission linkages were inferred when two sequences were ≤1.5% genetically different. Multiple linkages were resolved into putative transmission clusters. Further phylogenetic analyses were performed using BEAST v1.8.1. Finally, we investigated putative links between the 259 sequences from South-East Austria and all publicly available HIV polymerase sequences in the Los Alamos National Laboratory HIV sequence database. We found that 45.6% (118/259) of the sampled sequences were genetically linked with at least one other sequence from South-East Austria forming putative transmission clusters. Clustering individuals were more likely to be men who have sex with men (MSM; p<0.001), infected with subtype B (p<0.001) or subtype F (p = 0.02). Among clustered males who reported only heterosexual (HSX) sex as an HIV risk, 47% clustered closely with MSM (either as pairs or within larger MSM clusters). One hundred and seven of the 259 sequences (41.3%) from South-East Austria had at least one putative inferred linkage with sequences from a total of 69 other countries. In conclusion, analysis of HIV-1 sequences from newly diagnosed individuals residing in South-East Austria revealed a high degree of national and international clustering mainly within MSM. Interestingly, we found that a high number of heterosexual males clustered within MSM networks, suggesting either linkage between risk groups or misrepresentation of sexual risk behaviors by subjects.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged - epidemiology
- Child -
- Child, Preschool -
- Cluster Analysis -
- Female -
- HIV Infections - epidemiology
- Humans -
- Male -
- Middle Aged -
- Retrospective Studies -
- Spatio-Temporal Analysis -
- Young Adult -
- pol Gene Products, Human Immunodeficiency Virus - genetics