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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Ferrara, G; Annessi, G; Argenyi, Z; Argenziano, G; Beltraminelli, H; Cerio, R; Cerroni, L; Cota, C; Simonetti, S; Stefanato, CM; Zalaudek, I; Kittler, H; Soyer, HP.
Prior knowledge of the clinical picture does not introduce bias in the histopathologic diagnosis of melanocytic skin lesions.
J Cutan Pathol. 2015; 42(12):953-958 Doi: 10.1111/cup.12589 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Cerroni Lorenzo; Soyer Hans Peter; Zalaudek Iris
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Abstract:: A common debate among dermatopathologists is that prior knowledge of the clinical picture of melanocytic skin neoplasms may introduce a potential bias in the histopathologic examination. Histologic slides from 99 melanocytic skin neoplasms were circulated among 10 clinical dermatologists, all of them formally trained and board-certified dermatopathologists: 5 dermatopathologists had clinical images available after a 'blind' examination (Group 1); the other 5 had clinical images available before microscopic examination (Group 2). Data from the two groups were compared regarding 'consensus' (a diagnosis in agreement by ≥4 dermatopathologists/group), chance-corrected interobserver agreement (Fleiss' k) and level of diagnostic confidence (LDC: a 1-5 arbitrary scale indicating 'increasing reliability' of any given diagnosis). Compared with Group 1 dermatopathologists, Group 2 achieved a lower number of consensus (84 vs. 90) but a higher k value (0.74 vs. 0.69) and a greater mean LDC value (4.57 vs. 4.32). The same consensus was achieved by the two groups in 81/99 cases. Spitzoid neoplasms were most frequently controversial for both groups. The histopathologic interpretation of melanocytic neoplasms seems to be not biased by the knowledge of the clinical picture before histopathologic examination. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Find related publications in this database (Keywords): clinical information; clinicopathologic correlation; dermoscopy; histopathologic diagnosis; melanocytic skin; neoplasms