Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kiuru, M; Jungbluth, A; Kutzner, H; Wiesner, T; Busam, KJ.
Spitz Tumors: Comparison of Histological Features in Relationship to Immunohistochemical Staining for ALK and NTRK1.
Int J Surg Pathol. 2016; 24(3):200-206
Doi: 10.1177/1066896916630375
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Wiesner Thomas
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- Abstract:
- Spitz tumors are a group of melanocytic neoplasms with distinct morphological features that tend to affect young individuals. Distinguishing benign from malignant Spitz tumors can be challenging, but cytogenetic and molecular tests have contributed to improvements in diagnostic accuracy. Spitz tumors harbor diverse genetic alterations, including mutations in HRAS, loss of BAP1, or kinase fusions in ROS1, NTRK1, ALK, BRAF, and RET genes. Limited data exist on the correlation between histopathological features and kinase fusions. Here, we describe the histopathological features of 105 Spitz tumors (Spitz nevi and atypical Spitz tumors), comparing lesions according to their immunoreactivity for ALK or NTRK1. Intersecting fascicular growth of fusiform melanocytes was seen in all but one ALK-positive tumor (27 of 28 or 96.4%), whereas it was infrequent in NTRK1-positive tumors (5 of 20 or 25.0%) and tumors negative for both ALK and NTRK1 (96.4% vs 25.0% vs 8.7%, P < .0027). There was a trend toward ALK-positive tumors being amelanotic compared with NTRK1-positive tumors and combined ALK-/NTRK1-negative tumors (89.3% vs 45% vs 47.4%, respectively, P = .1023) and lacking epithelioid cell morphology (0% vs 45.0% vs 41%, respectively, P = .6985). In conclusion, this study confirms that although not specific, the growth pattern of intersecting fascicles of amelanotic fusiform melanocytes is strongly associated with ALK expression. © The Author(s) 2016.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Anaplastic Lymphoma Kinase -
- Biomarkers, Tumor - analysis
- Child -
- Child, Preschool -
- Female -
- Humans -
- Immunohistochemistry -
- In Situ Hybridization, Fluorescence -
- Male -
- Melanocytes - pathology
- Middle Aged -
- Nevus, Epithelioid and Spindle Cell - diagnosis
- Nevus, Epithelioid and Spindle Cell - pathology
- Receptor Protein-Tyrosine Kinases - analysis
- Receptor Protein-Tyrosine Kinases - biosynthesis
- Receptor, trkA - analysis
- Receptor, trkA - biosynthesis
- Skin Neoplasms - diagnosis
- Skin Neoplasms - pathology
- Young Adult -
- Find related publications in this database (Keywords)
- ALK
- NTRK1
- Spitz nevus
- immunohistochemistry