Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tubic, B; Magnusson, P; Mårild, S; Leu, M; Schwetz, V; Sioen, I; Herrmann, D; Obermayer-Pietsch, B; Lissner, L; Swolin-Eide, D; IDEFICS consortium.
Different osteocalcin forms, markers of metabolic syndrome and anthropometric measures in children within the IDEFICS cohort.
Bone. 2016; 84(5): 230-236.
Doi: 10.1016/j.bone.2016.01.008
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Theiler-Schwetz Verena
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- Abstract:
- Osteocalcin (OC), an aboundant non-collagenous bone protein, is inversely associated with parameters of glucose metabolism. Interactions between bone tissue and energy metabolism have not been thoroughly investigated during childhood. This study investigated OC, metabolic parameters and anthropometric characteristics in normal weight and overweight/obese children. This study comprised 108 (46 normal weight/62 overweight/obese) Swedish 2-9year old children. Anthropometric data, insulin, glucose, glycosylated haemoglobin (HbA1c), HOMA index, vitamin D, adiponectin, total OC, carboxylated OC (cOC) and undercarboxylated OC (ucOC) were analysed. No difference was found for total OC between the normal and overweight/obese groups, with a mean (±SD) value of 82.6 (±2.8) ng/mL and 77.0 (±2.4) ng/mL, (P=0.11), respectively. Overweight children had lower cOC levels, mean 69.1 (±2.2) ng/mL, vs. normal weight children, mean 75.6 (±2.5) ng/mL (P=0.03). The mean ucOC levels of 7.9 (±0.4) ng/mL in overweight children did not differ vs. normal weight children, mean level 7.0 (±0.4) ng/mL, (P=0.067). None of the three OC forms correlated with any of the measured parameters. The cOC levels were lower in overweight children. There was no correlation between the three OC forms and any of the measured anthropometric or metabolic parameters. OC has been suggested to have a possible metabolic role, but in general the current study in prepubertal children does not support the hypothesis of an association between OC and a positive metabolic profile. Copyright © 2016 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Anthropometry -
- Biomarkers - metabolism
- Child -
- Child, Preschool -
- Cohort Studies -
- Female -
- Humans -
- Male -
- Metabolic Syndrome X - blood
- Metabolic Syndrome X - metabolism
- Osteocalcin - blood
- Osteocalcin - metabolism
- Protein Isoforms - blood
- Statistics, Nonparametric -
- Sweden -
- Find related publications in this database (Keywords)
- Bone
- Osteocalcin
- Paediatric
- Fat mass
- Carboxylation