Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wutzl, A; Biedermann, E; Wanschitz, F; Seemann, R; Klug, C; Baumann, A; Watzinger, F; Schicho, K; Ewers, R; Millesi, G.
Treatment results of bisphosphonate-related osteonecrosis of the jaws.
Head Neck. 2008; 30(9): 1224-1230.
Doi: 10.1002/hed.20864
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Schicho Kurt
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- Abstract:
- Osteonecrosis of the jaws occurs after the administration of bisphosphonates. An unequivocal treatment strategy is yet to be devised. We assess the treatment of patients with bisphosphonate-related osteonecrosis of the jaws (BRONJ). The investigators studied a prospective cohort of 58 patients 6 months after surgical treatment of BRONJ. Outcome variables were the status of the mucosa, the visual analog score of pain, and prosthetic rehabilitation. Preoperative staging results were compared with the postoperative outcome and statistically evaluated. Of 58 patients, 41 surgically treated patients could be followed up after a mean period of 189 (+/-23) days. Twenty-four (58.5%) were free of pain and had an intact mucosa. A statistically significant improvement was registered between preoperative and postoperative staging (p <.01); 11 of 12 patients who had been treated with a flap procedure for soft tissue closure had an intact mucosa. This is the first prospective study to report the outcome of treatment in a cohort of patients with BRONJ. Minimal resection of necrotic bone and local soft tissue closure might be a feasible treatment strategy in patients with established BRONJ.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Age Distribution -
- Aged -
- Aged, 80 and over -
- Cohort Studies -
- Diphosphonates - administration & dosage Diphosphonates - adverse effects
- Dose-Response Relationship, Drug -
- Drug Administration Schedule -
- Female -
- Follow-Up Studies -
- Humans -
- Incidence -
- Injections, Intravenous -
- Jaw Diseases - chemically induced Jaw Diseases - epidemiology Jaw Diseases - pathology Jaw Diseases - surgery
- Male -
- Middle Aged -
- Osteonecrosis - chemically induced Osteonecrosis - epidemiology Osteonecrosis - pathology Osteonecrosis - surgery
- Osteoporosis - chemically induced Osteoporosis - drug therapy Osteoporosis - prevention & control
- Retrospective Studies -
- Severity of Illness Index -
- Sex Distribution -
- Find related publications in this database (Keywords)
- bisphosphonates
- osteonecrosis
- jaws
- prospective treatment outcomes
- surgery