Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hector, A; Kirn, T; Ralhan, A; Graepler-Mainka, U; Berenbrinker, S; Riethmueller, J; Hogardt, M; Wagner, M; Pfleger, A; Autenrieth, I; Kappler, M; Griese, M; Eber, E; Martus, P; Hartl, D.
Microbial colonization and lung function in adolescents with cystic fibrosis.
J Cyst Fibros. 2016; 15(3):340-349
Doi: 10.1016/j.jcf.2016.01.004
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Eber Ernst
- Pfleger Andreas
- Wagner Marlies
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- With intensified antibiotic therapy and longer survival, patients with cystic fibrosis (CF) are colonized with a more complex pattern of bacteria and fungi. However, the clinical relevance of these emerging pathogens for lung function remains poorly defined. The aim of this study was to assess the association of bacterial and fungal colonization patterns with lung function in adolescent patients with CF. Microbial colonization patterns and lung function parameters were assessed in 770 adolescent European (German/Austrian) CF patients in a retrospective study (median follow-up time: 10years). Colonization with Pseudomonas aeruginosa and MRSA were most strongly associated with loss of lung function, while mainly colonization with Haemophilus influenzae was associated with preserved lung function. Aspergillus fumigatus was the only species that was associated with an increased risk for infection with P. aeruginosa. Microbial interaction analysis revealed three distinct microbial clusters within the longitudinal course of CF lung disease. Collectively, this study identified potentially protective and harmful microbial colonization patterns in adolescent CF patients. Further studies in different patient cohorts are required to evaluate these microbial patterns and to assess their clinical relevance. Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Aspergillus fumigatus - isolation & purification
- Austria - epidemiology
- Cystic Fibrosis - epidemiology
- Cystic Fibrosis - microbiology
- Cystic Fibrosis - physiopathology
- Female -
- Germany - epidemiology
- Humans -
- Lung - microbiology
- Lung - physiopathology
- Male -
- Methicillin-Resistant Staphylococcus aureus - isolation & purification
- Microbial Interactions -
- Pseudomonas Infections - diagnosis
- Pseudomonas Infections - epidemiology
- Pseudomonas Infections - physiopathology
- Pseudomonas aeruginosa - isolation & purification
- Pulmonary Aspergillosis - diagnosis
- Pulmonary Aspergillosis - epidemiology
- Pulmonary Aspergillosis - physiopathology
- Respiratory Function Tests - methods
- Staphylococcal Infections - diagnosis
- Staphylococcal Infections - epidemiology
- Staphylococcal Infections - physiopathology
- Statistics as Topic -
- Find related publications in this database (Keywords)
- Cystic fibrosis
- Infection
- Bacteria
- Fungi
- Lung
- Colonization