Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Werkmeister, RM; Schmidl, D; Aschinger, G; Doblhoff-Dier, V; Palkovits, S; Wirth, M; Garhöfer, G; Linsenmeier, RA; Leitgeb, RA; Schmetterer, L.
Retinal oxygen extraction in humans.
Sci Rep. 2015; 5(5):15763-15763
Doi: 10.1038/srep15763
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- Co-authors Med Uni Graz
- Palkovits Stefan
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- Abstract:
- Adequate function of the retina is dependent on proper oxygen supply. In humans, the inner retina is oxygenated via the retinal circulation. We present a method to calculate total retinal oxygen extraction based on measurement of total retinal blood flow using dual-beam bidirectional Doppler optical coherence tomography and measurement of oxygen saturation by spectrophotometry. These measurements were done on 8 healthy subjects while breathing ambient room air and 100% oxygen. Total retinal blood flow was 44.3 ± 9.0 μl/min during baseline and decreased to 18.7 ± 4.2 μl/min during 100% oxygen breathing (P < 0.001) resulting in a pronounced decrease in retinal oxygen extraction from 2.33 ± 0.51 μl(O2)/min to 0.88 ± 0.14 μl(O2)/min during breathing of 100% oxygen. The method presented in this paper may have significant potential to study oxygen metabolism in hypoxic retinal diseases such as diabetic retinopathy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Blood Flow Velocity - physiology
- Blood Gas Analysis -
- Female -
- Humans -
- Intraocular Pressure - physiology
- Laser-Doppler Flowmetry -
- Male -
- Oxygen - analysis
- Radiography -
- Regional Blood Flow - physiology
- Retina - chemistry
- Retina - metabolism
- Retinal Vessels - diagnostic imaging
- Spectrophotometry -
- Tomography, Optical Coherence -
- Young Adult -