Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Balavarca, Y; Pearce, K; Norden, J; Collin, M; Jackson, G; Holler, E; Dressel, R; Kolb, HJ; Greinix, H; Socie, G; Toubert, A; Rocha, V; Gluckman, E; Hromadnikova, I; Sedlacek, P; Wolff, D; Holtick, U; Dickinson, A; Bickeböller, H.
Predicting survival using clinical risk scores and non-HLA immunogenetics.
Bone Marrow Transplant. 2015; 50(11):1445-1452
Doi: 10.1038/bmt.2015.173
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Previous studies of non-histocompatibility leukocyte antigen (HLA) gene single-nucleotide polymorphisms (SNPs) on subgroups of patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) revealed an association with transplant outcome. This study further evaluated the association of non-HLA polymorphisms with overall survival in a cohort of 762 HSCT patients using data on 26 polymorphisms in 16 non-HLA genes. When viewed in addition to an already established clinical risk score (EBMT-score), three polymorphisms: rs8177374 in the gene for MyD88-adapter-like (MAL; P=0.026), rs9340799 in the oestrogen receptor gene (ESR; P=0.003) and rs1800795 in interleukin-6 (IL-6; P=0.007) were found to be associated with reduced overall survival, whereas the haplo-genotype (ACC/ACC) in IL-10 was protective (P=0.02). The addition of these non-HLA polymorphisms in a Cox regression model alongside the EBMT-score improved discrimination between risk groups and increased the level of prediction compared with the EBMT-score alone (gain in prediction capability for EBMT-genetic-score 10.8%). Results also demonstrated how changes in clinical practice through time have altered the effects of non-HLA analysis. The study illustrates the significance of non-HLA genotyping prior to HSCT and the importance of further investigation into non-HLA gene polymorphisms in risk prediction.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Allografts -
- Cause of Death -
- Child -
- Estrogen Receptor alpha - genetics
- Female -
- Follow-Up Studies -
- Genotype -
- Graft vs Host Disease - mortality
- Haplotypes -
- Hematologic Neoplasms - mortality
- Hematologic Neoplasms - therapy
- Hematopoietic Stem Cell Transplantation - mortality
- Histocompatibility -
- Humans -
- Infection - mortality
- Interleukin-10 - genetics
- Interleukin-6 - genetics
- Kaplan-Meier Estimate -
- Male -
- Membrane Glycoproteins - genetics
- Middle Aged -
- Multiple Organ Failure - mortality
- Polymorphism, Single Nucleotide -
- Prognosis -
- Proportional Hazards Models -
- Receptors, Interleukin-1 - genetics
- Risk Assessment - methods
- Transplantation Conditioning - adverse effects
- Treatment Outcome -