Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kienesberger, S; Cox, LM; Livanos, A; Zhang, XS; Chung, J; Perez-Perez, GI; Gorkiewicz, G; Zechner, EL; Blaser, MJ.
Gastric Helicobacter pylori Infection Affects Local and Distant Microbial Populations and Host Responses.
Cell Rep. 2016; 14(6):1395-1407
Doi: 10.1016/j.celrep.2016.01.017
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- Führende Autor*innen der Med Uni Graz
- Kienesberger-Feist Sabine
- Co-Autor*innen der Med Uni Graz
- Gorkiewicz Gregor
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- Abstract:
- Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host's microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Bacterial - biosynthesis
- Disease Models, Animal -
- Female -
- Gastric Mucosa - immunology
- Gastric Mucosa - microbiology
- Gene Expression Profiling -
- Gene Expression Regulation -
- Helicobacter Infections - genetics
- Helicobacter Infections - immunology
- Helicobacter Infections - microbiology
- Helicobacter pylori - growth & development
- Helicobacter pylori - immunology
- Host-Pathogen Interactions -
- Humans -
- Immunity, Innate -
- Immunoglobulin G - biosynthesis
- Immunoglobulin M - biosynthesis
- Inflammation Mediators - immunology
- Lung - immunology
- Lung - microbiology
- Mice -
- Mice, Inbred C57BL -
- Microbiota - immunology
- Molecular Sequence Annotation -
- Signal Transduction -
- Stomach - immunology
- Stomach - microbiology