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Selected Publication:
Moran, O; Schreibmayer, W; Weigl, L; Dascal, N; Lotan, I.
Level of expression controls modes of gating of a K+ channel.
FEBS Lett. 1992; 302(1):21-25
Doi: 10.1016%2F0014-5793%2892%2980275-L
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- Co-authors Med Uni Graz
- Schreibmayer Wolfgang
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- Abstract:
- Several distinct subfamilies of K+ channel genes have been discovered by molecular cloning, however, in some cases the structural differences among them do not account for the diversity of K+ current types, ranging from transient A-type to slowly inactivating delayed rectifier-type, as members within each subfamily have been shown to code for K+ channels of different inactivation kinetics and pharmacological properties. We show that a single K+ channel cDNA of the Shaker subfamily (ShH4) can express in Xenopus oocytes not only a transient A-type K+ current but also, upon increased level of expression, slowly inactivating K+ currents with markedly reduced sensitivity to tetraethylammonium. In correlation with the macroscopic currents there are single-channel gating modes ranging from the fast-inactivation mode which underlies the transient A-type current, to slow-inactivation modes characterized by bursts of longer openings, and corresponding to the slowly inactivating macroscopic currents.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Drosophila -
- Electric Conductivity -
- Gene Expression Regulation -
- Ion Channel Gating -
- Kinetics -
- Potassium Channels - genetics
- RNA - metabolism
- Xenopus - metabolism
- Find related publications in this database (Keywords)
- Potassium Channel
- CDNA Expression
- Xenopus Oocyte
- Single-Channel Analysis
- Inactivation Kinetics