Medizinische Universität Graz - Research portal
Selected Publication:
Mayerhofer, K; Obermair, A; Windbichler, G; Petru, E; Kaider, A; Hefler, L; Czerwenka, K; Leodolter, S; Kainz, C.
Leiomyosarcoma of the uterus: a clinicopathologic multicenter study of 71 cases.
Gynecol Oncol. 1999; 74(2):196-201
Doi: 10.1006/gyno.1999.5436
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- Co-authors Med Uni Graz
- Petru Edgar
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- Abstract:
- OBJECTIVE: The aim of this study was to evaluate the behavior of uterine leiomyosarcomas in relation to their clinical and pathologic features and to identify possible prognostic factors. METHODS: Seventy-one patients with histologically proven uterine leiomyosarcoma were included in the analysis. Leiomyosarcomas were defined as uterine smooth-muscle tumors with five or more mitoses per 10 high-power fields and cytologic atypia. Cox proportional hazards regression model was used to identify independent prognostic factors. RESULTS: The median follow-up time was 108 months; 5-year overall survival rate was 65%. Evaluating the correlation between several clinicopathologic parameters, tumors with vascular space involvement had a statistically significantly higher stage than tumors without vasular space involvement (P = 0.015). In a univariate Cox model early tumor stage (P < 0.0001), age <50 years (P < 0.0001), low mitotic count (P = 0.05), and the absence of vascular space involvement (P < 0.0005) were associated with good prognosis. In a multivariate analysis age (P = 0.002), tumor stage (P = 0.004), vascular space involvement (P = 0.003), and mitotic count in stage I tumors (P = 0.002) were found to be independent parameters for good prognosis in patients with uterine leiomyosarcoma. CONCLUSION: Early tumor stage, age <50 years, and absence of vascular space involvement were independently associated with good prognosis. Mitotic count was detected to be a strong prognostic parameter in early tumor stage, but failed to act as an independent prognostic parameter in patients with tumor stage II-IV disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Female -
- Humans -
- Leiomyosarcoma - mortality
- Middle Aged - mortality
- Neoplasm Staging - mortality
- Prognosis - mortality
- Retrospective Studies - mortality
- Survival Rate - mortality
- Uterine Neoplasms - mortality
- Find related publications in this database (Keywords)
- Uterine Leiomyosarcoma
- Prognostic Factors
- Mitotic Count
- Vascular Space Involvement
- Stage