Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nayak, M; Eekhoff, ME; Peinhaupt, M; Heinemann, A; Desoye, G; van Poppel, MN.
Cytokines and their association with insulin resistance in obese pregnant women with different levels of physical activity.
Cytokine. 2016; 77(4):72-78
Doi: 10.1016/j.cyto.2015.11.003
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Desoye Gernot
- Heinemann Akos
- Peinhaupt Miriam
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- Abstract:
- Cytokines contribute to insulin resistance in pregnancy, but the role of distinct cytokines is not fully understood. To study whether cytokines produced by tissues other than skeletal muscle are associated with glucose and insulin metabolism activity in overweight and obese women and to study whether these associations can be modified by physical activity. A longitudinal study with 44 overweight and obese pregnant women was conducted. Changes in cytokines levels (IFN-γ, IP-10, IL1-α, MIP1-α, adiponectin and leptin) and ICAM1 from early (15wk) to late (32wk) pregnancy were determined. Physical activity was measured objectively with accelerometers. In linear regression models, the associations between (changes in) cytokine levels and fasting glucose, fasting insulin and HOMA-IR were studied. Both IFN-γ and IP-10 levels increased from early to late pregnancy, and adiponectin levels decreased. IFN-γ and IP-10 were positively associated with fasting glucose, whereas IL-1α, ICAM1 and adiponectin were inversely associated with insulin and insulin resistance. The association of IL-1α with insulin and insulin resistance was only found in women with low levels of physical activity. IFN-γ, IP-10, IL1-α, ICAM1, and adiponectin may play a role in glucose and insulin metabolism in pregnancy. The relationship of IL-1α with insulin and insulin resistance might be moderated by levels of physical activity. Further studies are required to confirm the role of these cytokines in glucose and insulin metabolism in obese pregnant women. Copyright © 2015 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Accelerometry -
- Adult -
- Blood Glucose - metabolism
- Chemokine CXCL10 - blood
- Cytokines - blood
- Exercise - physiology
- Fasting - blood
- Female -
- Humans -
- Insulin - blood
- Insulin Resistance - physiology
- Intercellular Adhesion Molecule-1 - blood
- Interferon-gamma - blood
- Interleukin-1alpha - blood
- Linear Models -
- Longitudinal Studies -
- Obesity - blood
- Obesity - physiopathology
- Overweight - blood
- Overweight - physiopathology
- Pregnancy -
- Pregnancy Complications - blood
- Pregnancy Complications - physiopathology
- Find related publications in this database (Keywords)
- Insulin resistance
- Cytokines
- Pregnancy