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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Te Grootenhuis, NC; van der Zee, AG; van Doorn, HC; van der Velden, J; Vergote, I; Zanagnolo, V; Baldwin, PJ; Gaarenstroom, KN; van Dorst, EB; Trum, JW; Slangen, BF; Runnebaum, IB; Tamussino, K; Hermans, RH; Provencher, DM; de Bock, GH; de Hullu, JA; Oonk, MH.
Sentinel nodes in vulvar cancer: Long-term follow-up of the GROningen INternational Study on Sentinel nodes in Vulvar cancer (GROINSS-V) I.
Gynecol Oncol. 2016; 140(1):8-14
Doi: 10.1016/j.ygyno.2015.09.077
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Tamussino Karl
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- Abstract:
- In 2008 GROINSS-V-I, the largest validation trial on the sentinel node (SN) procedure in vulvar cancer, showed that application of the SN-procedure in patients with early-stage vulvar cancer is safe. The current study aimed to evaluate long-term follow-up of these patients regarding recurrences and survival. From 2000 until 2006 GROINSS-V-I included 377 patients with unifocal squamous cell carcinoma of the vulva (T1, <4 cm), who underwent the SN-procedure. Only in case of SN metastases an inguinofemoral lymphadenectomy was performed. For the present study follow-up was completed until March 2015. Themedian follow-up was 105 months (range 0–179). The overall local recurrence ratewas 27.2% at 5 years and 39.5% at 10 years after primary treatment, while for SN-negative patients 24.6% and 36.4%, and for SN-positive patients 33.2% and 46.4% respectively (p = 0.03). In 39/253 SN-negative patients (15.4%) an inguinofemoral lymphadenectomy was performed, because of a local recurrence. Isolated groin recurrence rate was 2.5% for SN-negative patients and 8.0% for SN-positive patients at 5 years. Disease-specific 10-year survival was 91% for SN-negative patients compared to 65% for SN-positive patients (p b .0001). For all patients, 10-year disease-specific survival decreased from 90% for patients without to 69% for patients with a local recurrence (p b .0001).
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Squamous Cell - diagnosis
- Carcinoma, Squamous Cell - pathology
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Humans -
- Lymph Nodes - pathology
- Lymphatic Metastasis -
- Middle Aged -
- Neoplasm Recurrence, Local - diagnosis
- Neoplasm Recurrence, Local - pathology
- Reproducibility of Results -
- Sentinel Lymph Node Biopsy - methods
- Sentinel Lymph Node Biopsy - standards
- Vulvar Neoplasms - diagnosis
- Vulvar Neoplasms - pathology
- Find related publications in this database (Keywords)
- Vulvar cancer
- Sentinel node
- Long-term follow-up