Medizinische Universität Graz - Research portal
Selected Publication:
Felsner, P; Hofer, D; Rinner, I; Porta, S; Korsatko, W; Schauenstein, K.
Adrenergic suppression of peripheral blood T cell reactivity in the rat is due to activation of peripheral alpha 2-receptors.
J Neuroimmunol. 1995; 57(1-2):27-34
Doi: 10.1016%2F0165-5728%2894%2900158-K
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- Co-authors Med Uni Graz
- Porta Sepp
- Schauenstein Konrad
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- Abstract:
- A 20-h treatment of rats with catecholamines using s.c.implantable retard tablets markedly suppresses the in vitro reactivity of peripheral blood (PBL) T lymphocytes, provided that beta-receptors are blocked with propranolol (Felsner et al., 1992). The results can be summarized as follows: (i) the suppressive effect of noradrenaline+propranolol to the concanavalin A (ConA) response of PBL was abolished by the simultaneous application of the alpha-blocker phentolamine. Using selective agonists, the relevant receptor was identified to belong to the alpha 2-subtype. (ii) The alpha-adrenergic suppression of the PBL T cell response was likewise observed in adrenalectomized animals, which rules out the participation of secondarily induced glucocorticoids. Furthermore, the combination of noradrenaline with the watersoluble beta-blocker nadolol was equally effective to suppress the ConA response of PBL. (iii) An analogous alpha-mediated suppression of T cell function of PBL, but not spleen cells, was observed 1 h after i.p. treatment with tyramine, which leads to the release of endogenous noradrenaline. From these results it is concluded that the adrenergic suppression of PBL T cell functions is primarily due to the activation of peripheral alpha 2-receptors and that it is likewise observed under acute indirect sympathomimetic treatment.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Concanavalin A - pharmacology
- Immunosuppressive Agents - pharmacology
- Male - pharmacology
- Norepinephrine - pharmacology
- Rats - pharmacology
- Rats, Sprague-Dawley - pharmacology
- Receptors, Adrenergic, alpha-2 - physiology
- Sympathomimetics - pharmacology
- T-Lymphocytes - drug effects
- Tyramine - pharmacology
- Find related publications in this database (Keywords)
- Catecholamine
- Alpha-Adrenergic Receptor
- Peripheral Blood Lymphocyte
- T Lymphocyte
- Immune Response