Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heitzer, E; Ulz, P; Geigl, JB; Speicher, MR.
Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.
Mol Oncol. 2016; 10(3):494-502
Doi: 10.1016/j.molonc.2015.12.004
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- Führende Autor*innen der Med Uni Graz
- Heitzer Ellen
- Speicher Michael
- Co-Autor*innen der Med Uni Graz
- Geigl Jochen Bernd
- Ulz Peter
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- Abstract:
- Liquid biopsies, i.e. the analysis of circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA), are evolving into promising clinical tools. Indeed, a plethora of liquid biopsy technologies to deduce non-invasively characteristics of the tumor genome from the peripheral blood have been developed over the last few years. For example, liquid biopsies have been used to assess the tumor burden, to monitor the evolution of tumor genomes, to unravel mechanisms of resistance, to establish the tumor heterogeneity, and for the identification of prognostic and predictive markers. In this review we focus on methods to establish genome-wide profiles of somatic copy number alterations (SCNAs) from plasma DNA and show how they provide novel insights into the biology of cancer and their impact on the management of patients. Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- Find related publications in this database (Keywords)
- Circulating tumor cells (CTCs)
- Circulating tumor DNA (ctDNA)
- Plasma DNA
- Whole-genome sequencing
- Somatic copy number alterations