Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Herbert, MK; Hering, S.
Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting capsaicin-induced vasodilatation in the rat skin.
Eur J Pharmacol. 1995; 286(3):273-279
Doi: 10.1016/0014-2999(95)00456-0
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- Führende Autor*innen der Med Uni Graz
- Herbert Michael K.
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- Abstract:
- The effect of tumor necrosis factor-alpha (TNF alpha) and tumor necrosis factor-beta (TNF beta) on the capsaicin-induced increase in cutaneous blood flow was investigated in anaesthetized rats. Skin blood flow was measured by laser-Doppler flowmetry. Intraplantar subcutaneous injections of 5-500 pg TNF alpha and 50-5000 pg TNF beta had no effect on local blood flow, whereas 5000 pg TNF alpha induced a transient hyperaemia. However, neither the pretreatment with TNF alpha (5-5000 pg) nor that with TNF beta (50-5000 pg) enhanced the vasodilatator response to intraplantar capsaicin (0.03 micrograms; 0.1 microgram), whereas 50 pg interleukin-1 beta augmented the capsaicin-induced hyperaemia (P < 0.05). This enhancement of the cutaneous hyperaemic response to capsaicin was absent when interleukin-1 beta (50 pg) was co-injected with TNF alpha (500 pg or 5000 pg). The vasodilatation caused by calcitonin gene-related peptide or bradykinin was not altered by 500 pg or 5000 pg TNF alpha. These data indicate that TNFs, in contrast to interleukin-1 beta, do not amplify the hyperaemic response to afferent nerve stimulation with capsaicin but reverse the augmentation mediated by interleukin-1 beta.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Blood Pressure - drug effects
- Bradykinin - pharmacology
- Calcitonin Gene-Related Peptide - pharmacology
- Capsaicin - pharmacology
- Female -
- Hyperemia - chemically induced
- Interleukin-1 - pharmacology
- Lymphotoxin-alpha - pharmacology
- Rats -
- Rats, Sprague-Dawley -
- Skin - blood supply
- Tumor Necrosis Factor-alpha - pharmacology
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- TNF-ALPHA (TUMOR NECROSIS FACTOR-ALPHA)
- CAPSAICIN
- CUTANEOUS HYPEREMIA
- AFFERENT NERVE STIMULATION
- CGRP (CALCITONIN GENE-RELATED PEPTIDE)
- BRADYKININ