Medizinische Universität Graz - Research portal
Selected Publication:
Herbert, MK; Just, H; Schmidt, RF.
Histamine excites groups III and IV afferents from the cat knee joint depending on their resting activity.
Neurosci Lett. 2001; 305(2):95-98
Doi: 10.1016/S0304-3940(01)01817-1
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- Leading authors Med Uni Graz
- Herbert Michael K.
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- Abstract:
- The effect of histamine on the sensory activity of primary afferents was studied in normal and acutely inflamed cat knee joints. A subpopulation of groups III and IV articular afferents could be activated by close-arterial bolus injections of histamine: units with a high resting activity (about 100/min) were particular sensitive to histamine and were excited even by 3.3 fg histamine. The lower the resting discharges of groups III and IV units both from normal and acutely inflamed joints, the higher the dose of histamine (up to 3.3 or 33 microg) necessary to excite the nerve fibres. Thirty-seven of 39 units without any resting activity were completely insensitive to histamine. In contrast to its clear excitatory effect, histamine caused only minor changes in the responses to joint movements. Movement-evoked activity remained unchanged in 22 of 28 units, 1 unit was sensitized and 5 units showed reduced activity after histamine (3.3 microg). The present results support the notion that histamine may participate in the mediation of pain from injured or inflamed tissue. It is remarkable that histamine has a profound excitatory action on a proportion of both groups III and IV articular afferents without changing their sensitivity to joint movements.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Animals -
- Arthritis - physiopathology
- Cats -
- Dose-Response Relationship, Drug -
- Electrophysiology -
- Female -
- Histamine - pharmacology
- Injections, Intra-Arterial -
- Knee Joint - innervation Knee Joint - physiopathology
- Male -
- Motor Activity - drug effects
- Nerve Fibers - drug effects Nerve Fibers - physiology
- Neurons, Afferent - classification Neurons, Afferent - drug effects Neurons, Afferent - physiology
- Neurotoxins - pharmacology
- Reference Values -
- Rest -
- Find related publications in this database (Keywords)
- histamine
- knee joint
- inflammation
- arthritis
- pain