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Tafler, R; Herbert, MK; Schmidt, RF; Weis, KH.
Small reduction of capsaicin-induced neurogenic inflammation in human forearm skin by the glucocorticoid prednicarbate.
Agents Actions. 1993; 38 Spec No(3):C31-C34 Doi: 10.1007/BF01991128
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Co-authors Med Uni Graz: Herbert Michael K.
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Abstract:: Capsaicin applied to human skin provokes a response known as neurogenic inflammation. Neuropeptides (substance P, CGRP), released from afferent C-fiber terminals and histamine, secondarily released from mast cells, are supposed to participate in this reaction. We investigated the contribution of arachidonic acid and metabolic products to neurogenic inflammation, using a potent topically applied glucocorticoid and the corresponding vehicle. Arachidonic acid is liberated from membrane phospholipids by phospholipase A2, an enzyme that can be blocked by glucocorticoids. In 12 healthy volunteers, neurogenic inflammation was induced by capsaicin 1% on both upper forearms after 16 h of topical pretreatment with either prednicarbate or vehicle. Neurogenic inflammation was assessed by laser Doppler flowmetry and by planimetry of flare sizes. Prednicarbate significantly reduced the laser Doppler flow values inside the flare responses, as well as the flare sizes themselves. These results show that to some extent glucocorticoids reduce capsaicin-induced neurogenic inflammation.
Find related publications in this database (using NLM MeSH Indexing): Administration, Topical -; Adult -; Anti-Inflammatory Agents - pharmacology; Capsaicin - adverse effects; Dermatitis, Contact - physiopathology Dermatitis, Contact - prevention & control; Forearm -; Humans -; Ointments -; Pharmaceutical Vehicles -; Prednisolone - analogs & derivatives Prednisolone - pharmacology; Regional Blood Flow - drug effects; Skin - blood supply Skin - drug effects Skin - innervation