Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Lindner, E; Glatz, W; Schwab, C; El-Shabrawi, Y; Mossböck, G.
Analysis of functional polymorphisms in apoptosis-related genes in primary open angle glaucoma.
Mol Vis. 2015; 21(7):1340-1344 [OPEN ACCESS]
Web of Science PubMed

Führende Autor*innen der Med Uni Graz: Lindner Ewald
Co-Autor*innen der Med Uni Graz: El-Shabrawi Yosuf; Glatz Wilfried Maximilian; Mossböck Georg; Schwab Christoph
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Abstract:: Glaucoma is a disease with high heritability in which the degradation of retinal ganglion cells occurs via apoptosis. Therefore, we investigated the role of four functional apoptosis-related gene variants (Akt1 rs1130233, Bax rs4645878, Fas rs223476, and FasL rs763110) in patients with primary open angle glaucoma. 334 patients with primary open angle glaucoma and 334 controls were recruited for this case-control study. The main outcome measures were genotype distribution and allelic frequencies determined with PCR. After adjustment for multiple testing, no significant difference in either the genotype distribution or the allelic frequencies of any investigated gene variant was found. Our findings indicate that the investigated gene polymorphisms are unlikely to be major risk factors for primary open angle glaucoma in Caucasian patients.
Find related publications in this database (using NLM MeSH Indexing): Aged -; Aged, 80 and over -; Apoptosis - genetics; Case-Control Studies -; European Continental Ancestry Group - genetics; Fas Ligand Protein - genetics; Female -; Gene Frequency -; Genetic Association Studies -; Genotype -; Glaucoma, Open-Angle - genetics; Glaucoma, Open-Angle - pathology; Humans -; Male -; Middle Aged -; Polymorphism, Single Nucleotide -; Proto-Oncogene Proteins c-akt - genetics; Retrospective Studies -; bcl-2-Associated X Protein - genetics; fas Receptor - genetics