Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dehghan Esmatabadi, MJ; Farhangi, B; Safari, Z; Kazerooni, H; Shirzad, H; Zolghadr, F; Sadeghizadeh, M.
Dendrosomal curcumin inhibits metastatic potential of human SW480 colon cancer cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 gene expression.
Asian Pac J Cancer Prev. 2015; 16(6):2473-2481
Doi: 10.7314/APJCP.2015.16.6.2473
[OPEN ACCESS]
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Safari Zahra
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advanced colorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, there is a need for effective anti-metastasis therapeutic agents. Since a great body of research has indicated anticancer effects for curcumin, we investigated the effects of dendrosomal curcumin (DNC) on cellular migration and adhesion of human SW480 cells and possible molecular mechanisms involved. Different methods were applied in this study including MTT, Scratch and adhesion assays as well as real-time PCR and transwell chamber assays. Based on the results obtained, DNC inhibits metastasis by decreasing Hef 1, Zeb 1 and Claudin 1 mRNA levels and can reduce SW480 cell proliferation with IC50values of 15.9, 11.6 and 7.64 μM at 24, 48 and 72 h post-treatment. Thus it might be considered as a safe formulation for therapeutic purpose in colorectal cancer cases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adaptor Proteins, Signal Transducing - antagonists & inhibitors
- Adaptor Proteins, Signal Transducing - genetics
- Adaptor Proteins, Signal Transducing - metabolism
- Antineoplastic Agents - pharmacology
- Apoptosis - drug effects
- Blotting, Western -
- Cell Adhesion - drug effects
- Cell Movement - drug effects
- Cell Proliferation - drug effects
- Claudin-1 - antagonists & inhibitors
- Claudin-1 - genetics
- Claudin-1 - metabolism
- Colonic Neoplasms - drug therapy
- Colonic Neoplasms - metabolism
- Colonic Neoplasms - secondary
- Curcumin - chemistry
- Curcumin - pharmacology
- Drug Carriers -
- Gene Expression Regulation, Neoplastic - drug effects
- Homeodomain Proteins - antagonists & inhibitors
- Homeodomain Proteins - genetics
- Homeodomain Proteins - metabolism
- Humans -
- Immunoenzyme Techniques -
- Nanocapsules - administration & dosage
- Phosphoproteins - antagonists & inhibitors
- Phosphoproteins - genetics
- Phosphoproteins - metabolism
- RNA, Messenger - genetics
- Real-Time Polymerase Chain Reaction -
- Reverse Transcriptase Polymerase Chain Reaction -
- Transcription Factors - antagonists & inhibitors
- Transcription Factors - genetics
- Transcription Factors - metabolism
- Tumor Cells, Cultured -
- Zinc Finger E-box-Binding Homeobox 1 -