Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Nematollahi-Mahani, SN; Azizollahi, GH; Baneshi, MR; Safari, Z; Azizollahi, S.
Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy.
Andrologia. 2014; 46(3): 240-245.
Doi: 10.1111/and.12067
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Safari Zahra
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma antioxidant defence levels after folic acid and zinc sulphate administration in varicocelectomised patients. Participants were randomly allocated to four experimental groups. Our randomisation schedule was as follows: zinc sulphate/folic acid, folic acid, zinc sulphate and placebo. The patients underwent varicocelectomy, before which a blood and semen sample were obtained and also three and six months after varicocelectomy for evaluation of blood hormonal level (FSH, testosterone, inhibin B) and seminal oxidative stress status (nitric oxide, superoxide dismutase, total antioxidant capacity). Patients in different groups took orally one capsule per day after dinner following varicocelectomy for 6 months. A significant rise in peripheral blood inhibin B and seminal plasma activity was detected in the zinc sulphate/folic acid group after 6 months. The present clinical trial indicates a change in the hormonal status of varicocelectomised patients following long-term administration of zinc sulphate and folic acid. © 2013 Blackwell Verlag GmbH.
- Find related publications in this database (using NLM MeSH Indexing)
- Antioxidants - metabolism
- Drug Therapy, Combination -
- Folic Acid - administration & dosage Folic Acid - therapeutic use
- Follicle Stimulating Hormone - blood
- Humans -
- Infertility, Male - drug therapy Infertility, Male - etiology Infertility, Male - metabolism
- Inhibins - blood
- Male -
- Nitric Oxide - metabolism
- Semen - drug effects Semen - metabolism
- Superoxide Dismutase - metabolism
- Testosterone - blood
- Varicocele - complications Varicocele - drug therapy Varicocele - metabolism
- Zinc Sulfate - administration & dosage Zinc Sulfate - therapeutic use
- Find related publications in this database (Keywords)
- Folic acid
- varicocele
- zinc sulphate