Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mahmoodi, M; Alizadeh, AM; Sohanaki, H; Rezaei, N; Amini-Najafi, F; Khosravi, AR; Hosseini, SK; Safari, Z; Hydarnasab, D; Khori, V.
Impact of fumonisin B1 on the production of inflammatory cytokines by gastric and colon cell lines.
Iran J Allergy Asthma Immunol. 2012; 11(2): 165-173.
Doi: 011.02/ijaai.165173
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Safari Zahra
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Fumonisins, a family of mycotoxins, are mainly toxic and carcinogenic. The present study was carried out to evaluate fumonisin B1 (FB1) effects on the production of inflammatory cytokines by gastric and colon cell lines. The study was performed on two cell lines under in vitro condition, including gastric epithelial cell line (AGS) and human colon adenocarcinoma cell line (SW742). Lipopolysaccharide (LPS) was used for inflammatory cytokine induction. The culture medium was supplemented with 4.5-72 mg/l of FB1 for 72 h before cell induction. The supernatants were harvested 24 h after the induction and measured for cytokines by using enzyme-linked immunosorbent assay.FB1 induced a dose-dependent increase in the production of tumor necrosis factor-α and interleukin-1β in both AGS and SW742 cell lines. This increase was statistically significant with concentration of FB1 between 9 and 72 mg/l (P < 0.05). FB1 also induced a dose-dependent decrease in interleukin-8 production. This decrease was seen in both cell lines and showed a statistical significance with FB1 concentration (P < 0.05).The results show that FB1 increases inflammatory cytokines production by various gastric and intestinal cells. This effect in the long run can possibly be the basis for the occurrence or development of inflammation and subsequent atrophy in the above-mentioned tissues.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Line, Tumor -
- Colon - drug effects Colon - immunology
- Culture Media, Conditioned - metabolism
- Cytokines - metabolism
- Dose-Response Relationship, Drug -
- Enzyme-Linked Immunosorbent Assay -
- Fumonisins - toxicity
- Humans -
- Inflammation Mediators - metabolism
- Interleukin-1beta - metabolism
- Interleukin-8 - metabolism
- Stomach - drug effects Stomach - immunology
- Time Factors -
- Tumor Necrosis Factor-alpha - metabolism
- Find related publications in this database (Keywords)
- Colon
- Fumonisin B1
- Gastric
- IL-1 beta
- IL-8
- TNF-alpha